Grape juice inactivated human enteroviruses, but not parainfluenza type 1 (Sendai) virus, in vitro. The effect was not one of aggregation or of degradation of the virus surface. Some of the inactivated virus adsorbed specifically to host cells, but did not infect them. Most of the inactivated virus could be reactivated by treatment with polyethylene glycol. Grape juice-inactivated virus and coproantibody-neutralized virus were both reactivated by contents of porcine stomach and duodenum, which suggests that ingestion of such viruses would lead to intestinal infection. Grape juice-inactivated virus was efficiently reactivated by human blood serum. Ingested grape juice has not been shown likely to prevent or modify human enterovirus infections.

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