The sensitivity of 253 Staphylococcus aureus strains isolated from a Nigerian locally-fermented cereal drink (kunun zaki) to 11 antimicrobial agents was determined. Two hundred and forty-seven (97.6%) strains were resistant to one or more of the antimicrobial agents and only 4 (1.6%) isolates were sensitive to all of the agents. Of the isolates from the kunun zaki preparation, 97.8% were resistant while 98.6% from kunun zaki bought at sale outlet and 96.7% of those isolated from utensils were resistant. There was no significant difference in resistance of isolates from the sources (P>0.05, X2). Resistance to penicillin (92.9%), ampicillin (92.9%) and trimethoprim (80.2%) was most frequently encountered while fewer isolates wereresistant to gentamycin (2.0%) and neomycin (3.6%). The predominant antimicrobial resistance pattern was ampicillin-penicillin-trimethoprim detected in 43 (17.0%) strains. The relatively high resistance of S. aureus strains isolated from kunun zaki to the tested antimicrobial agents is suggestive of misuse of those drugs in Nigeria.
1Department of Veterinary Pathology and Microbiology