V79 Chinese hamster cells and Molt-4 human cells have been used to test the cellular and genetic toxicities of o-tyrosine addition at concentrations far in excess of that found after irradiation of chicken to 10 kGy (~1.3 μg/ml). No toxicity, as measured by sister chromatid exchange, micronuclei formation, or reproductive death, was seen in cells exposed to concentrations up to 100 μg/ml o-tyrosine. After 2 d in 200 μg/ml o-tyrosine, Molt-4 cells had a higher percentage of dead cells in the population, but the growth rate and micronuclei formation were not affected.
An Evaluation of the Genotoxicity of O-Tyrosine, a Proposed Marker for Irradiated Food
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JOSEPH G. SZEKELY, NOEMI CHUAQUI-OFFERMANNS, MARLENE GOODWIN, SABINE DELANEY; An Evaluation of the Genotoxicity of O-Tyrosine, a Proposed Marker for Irradiated Food. J Food Prot 1 December 1992; 55 (12): 1006–1008. doi: https://doi.org/10.4315/0362-028X-55.12.1006
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