Distribution and residue depletion patterns of oxytetracycline were examined in giant freshwater prawns, Macrobrachium rosenbergii, after medicated-feed treatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The concentration of oxytetracycline in prawn muscle tissues was measured using high-performance liquid chromatography equipped with a fluorescence detector. The limit of detection was 0.1 μg/g. In the medicated-feed–treated group, oxytetracycline was detectable 8 days posttreatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The depletion half-life and mean residence time of oxytetracycline were 30.96 and 100.3 h, respectively. The dose of 4 g/kg of feed for 5 consecutive days can be recommended for therapeutic dosage regimen in giant freshwater prawn aquaculture. The minimal withdrawal period of M. rosenbergii muscle tissue should be 8 days postcessation of medicated feed.
Distribution and Residue Depletion of Oxytetracycline in Giant Freshwater Prawn (Macrobrachium rosenbergii )
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AMNART POAPOLATHEP, SARANYA POAPOLATHEP, KANJANA IMSILP, NUTTHAPONG WANNAPAT, NARUMOL KLANGKAEW, NAPASORN KUSUTJARIT, SUSUMU KUMAGAI; Distribution and Residue Depletion of Oxytetracycline in Giant Freshwater Prawn (Macrobrachium rosenbergii ). J Food Prot 1 April 2008; 71 (4): 870–873. doi: https://doi.org/10.4315/0362-028X-71.4.870
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