Six juvenile tegus were used in a crossover study to evaluate sedation and antinociception using 0.2 mg/kg dexmedetomidine, 1 mg/kg midazolam, and 0.2 mg/kg dexmedetomidine combined with 1 mg/kg midazolam. Saline was used as a negative control. All animals were housed in similar environmental conditions and deemed healthy by means of physical examination, complete blood counts, and serum chemistry measurements. Each trial combination was given by intramuscular injection into the biceps brachii with at least a two-week washout between trials. Sedation was determined by visual observation, resistance to restraint, and thoracic limb righting reflex. Antinociception was measured following exposure to thermal noxious stimulation and mechanical noxious stimulation measured by clamping a hemostat over a digit. Sedation was noted in the midazolam group and more profoundly in the dexmedetomidine-midazolam groups, but not in the dexmedetomidine group. Toe clamp reaction was present in...

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