An 8-yr-old male bearded dragon (Pogona vitticeps) presented with lethargy, inappetence, and skin discoloration. Dorsoventral whole body radiographs revealed a homogenous left coelomic mass. A complete blood count revealed leukocytosis and monocytosis, while the plasma biochemistry revealed hypercalcemia, elevated lactate, and elevated creatinine. Coelomic ultrasonography was performed to further characterize the mass before surgical exploration and removal. Ultrasonography revealed a hyperechoic mass that was vascular with a hypoechoic, avascular center consistent with fluid accumulation. An exploratory coeliotomy was performed and the left fat body containing the mass was removed en bloc for histopathologic evaluation. Oil Red O staining confirmed a diagnosis of liposarcoma. Continued decline after discharge prompted a decision to euthanize the patient. Unfortunately, a necropsy was not elected.

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