The coccidian parasite Choleoeimeria pogonae infests the biliary ducts and gallbladder of the central bearded dragon, Pogona vitticeps . Endogenous Choleoeimeria development occurs in the epithelium of the gallbladder and bile ducts, leading to significant tissue injury. To determine whether bile composition in the gallbladder was disrupted by the parasite, bile samples were collected from one normal and one Choleoeimeria infested central bearded dragons. Bile acid species were identified and quantified with liquid chromatography and mass spectroscopy. Tauroallochoic acid was the predominant bile acid (82.2%) in the normal bearded dragon. Whereas, the deconjugated allocholic acid was the predominant bile acid (40.1%) in the bearded dragon with Choleoeimeria. Taurine conjugation inhibits calcium precipitation in bile and bile acid mediated ductal epithelial cytotoxicity. The shift in bile acid content identified in the Choleoeimeria infested bearded dragon may contribute to cholelithiasis and mucosal damage.
Choleoeimeria pogonae alters the bile acid composition of the central bearded dragon, Pogona vitticeps
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Andrea Johnston, Anke C. Stöhr, Charles Artiles, Nathalie Rademacher; Choleoeimeria pogonae alters the bile acid composition of the central bearded dragon, Pogona vitticeps. Journal of Herpetological Medicine and Surgery 2021; doi: https://doi.org/10.5818/JHMS-D-20-00009
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