Over a 3-month period, a 6-yr-old, wild-caught, northern leopard frog ( Lithobates pipiens ) presented for reoccurring cloacal prolapse, despite surgical correction. Two contrast radiographic series performed approximately 6 wk apart showed intestinal obstruction and gastrointestinal dysmotility, while exploratory coeliotomy revealed a minor intestinal intussusception. Approximately 6 months after the fourth and final prolapse had resolved, the animal died of natural causes. Necropsy examination exposed a large, ill-defined thickening of the distal intestinal wall, with proximal intestinal dilation. Histopathology revealed a mass composed of polygonal cells, with occasional intracytoplasmic mucin arranged in sheets, and poorly formed acini, consistent with an intestinal adenocarcinoma. A presumptive metastatic lesion was identified in the kidney (microscopically). Herpesvirus-specific consensus polymerase chain reaction (PCR) and nested PCR assays performed on the formalin-fixed, paraffin-embedded intestinal and kidney masses for ranid herpesvirus 1 were negative. Few reports of intestinal adenocarcinoma in amphibians exist in the literature. To the authors' knowledge, this represents the first report of spontaneous intestinal adenocarcinoma in a northern leopard frog.

ABSTRACT A corn snake, Elaphe guttata guttata , presented with a six week history of anorexia and a lateralized soft tissue mass in the caudal 1/3 of the snake. Due to the obstipation caused by the mass, excisional biopsy was performed and the mass submitted for microscopic evaluation. Histopathology revealed an infiltrative lipoma. The snake was later euthanized due to necrosis and dehiscence at the surgical site, a spinal fracture unrelated to the mass, and cardiac tamponade.