Modern science can reduce frostbite and prevent loss of life in cold-water and cold-air environments by utilizing 2,4-dinitrophenol (DNP), a drug capable of warming the body. This chemical is presently available to simulate thermogenesis, i.e., replicate physiologic processes by increasing body metabolism at the cellular level. With this substance, modern science can reduce the dangers of freezing encountered in hostile waters, on the winter battlefield, and on recreational snow slopes. The Institute of Specialized Medicine (ISM) has begun a three-phase testing program to determine the efficacy of the drug DNP for survival in emergency situations. Testing in the first stage comprises animal studies, utilizing rats in cold-air dry units and water-filled vats; the second stage will utilize dogs and primates; the third stage will study humans in cold-air and cold-water scenarios. Subjects will be tested in temperatures at 0°C (32°F), 10°C (50°F), and 20°C (68°F) with and without clothing. Data on metabolic thermogenesis, skin and rectal temperatures, heart and arterial functioning, and oxygen consumption will be monitored and recorded by computerized instrumentation.

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