The aim of this study was to clinically evaluate the guided bone regeneration (GBR) potential of allograft, xenograft, and alloplastic materials in combination with resorbable membranes in extraction sockets. The qualitative and quantitative assessments of this prospective study were accomplished through histologic and histomorphometric analysis. Three experimental groups and 1 control group for comparison (n = 8) received either an allograft (human cancellous bone, freeze dried, Deutsches Institut für Zell und Gewebeersatz, Berlin, Germany), xenograft (BioOss, Geistlich Pharma AG, Wolhusen, Switzerland), or alloplast (biphasic calcium sulphate, Bondbone, MIS Implants Technologies Ltd., Charlotte, NC). The negative control group received no regenerative material. Tissue samples were then qualitatively and quantitatively evaluated as a function of percentage of new vital bone, graft particles content, soft tissue, and bone marrow over time. All 3 study groups presented bone volume suitable for the successful placement of a dental implant. The xenograft group yielded significantly less amount of vital bone compared with the allograft and alloplast groups. When comparing the percentage of residual graft particles, there was significantly greater amounts associated with the xenograft group in contrast to the allograft and alloplast groups. Similarly, a significantly increased amount of soft tissue percentage was observed within the xenograft group relative to all other groups. No significant differences were observed in the percentage of residual graft particles between the allograft and alloplast groups. There were also no significant differences detected in vital bone percentage between the allograft, alloplast, and control groups. When evaluating the bone marrow percentage, the only significant difference detected was between the xenograft and alloplast materials. Overall, no complications (ie, fever, malaise, purulence or fistula) were observed during the entirety of clinical trial among all patients. The greatest GBR potential was associated with the allograft material because of the greater degree of vital bone and the lowest percentage of residual graft particles. All studied bone substitute materials resulted in bone apposition for efficient use in alveolar ridge preservation procedures.
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December 2022
CLINICAL|
April 21 2022
A Histologic and Histomorphometric Evaluation of an Allograft, Xenograft, and Alloplast Graft for Alveolar Ridge Preservation in Humans: A Randomized Controlled Clinical Trial
Eirini Zampara, DMD;
Eirini Zampara, DMD
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
2 Department of Dental Implants and Tissue Regeneration, Hygeia Hospital, Marousi, Greece.
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Mukhlid Alshammari, BS, BDS;
Mukhlid Alshammari, BS, BDS
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
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Joao De Bortoli, DDS, PhD;
Joao De Bortoli, DDS, PhD
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
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Otto Mullings, BS;
Otto Mullings, BS
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
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Ioannis G. Gkisakis, DDS;
Ioannis G. Gkisakis, DDS
3 Department of Oral Medicine and Pathology, University of Athens School of Dentistry, Athens, Greece.
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Ernesto B. Benalcázar Jalkh, DDS, PhD;
Ernesto B. Benalcázar Jalkh, DDS, PhD
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
4 Department of Prosthodontics and Periodontology, University of Sao Paulo, Bauru School of Dentistry, Bauru, SP, Brazil.
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Nick Tovar, PhD, DDS, PhD;
Nick Tovar, PhD, DDS, PhD
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
5 Department of Oral and Maxillofacial Surgery, New York University, Langone Medical Center and Bellevue Hospital Center, New York, New York, USA.
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Paulo G. Coelho, MD, DDS, PhD, MBA;
Paulo G. Coelho, MD, DDS, PhD, MBA
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
6 Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
7 Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
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Lukasz Witek, MSc, PhD
Lukasz Witek, MSc, PhD
*
1 Biomaterials Division, New York University College of Dentistry, New York, New York, USA.
8 Department of Biomedical Engineering, Tandon School of Engineering, New York University, Brooklyn, New York, USA.
* Corresponding author, e-mail:lukasz.witek@nyu.edu
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J Oral Implantol (2022) 48 (6): 541–549.
Citation
Eirini Zampara, Mukhlid Alshammari, Joao De Bortoli, Otto Mullings, Ioannis G. Gkisakis, Ernesto B. Benalcázar Jalkh, Nick Tovar, Paulo G. Coelho, Lukasz Witek; A Histologic and Histomorphometric Evaluation of an Allograft, Xenograft, and Alloplast Graft for Alveolar Ridge Preservation in Humans: A Randomized Controlled Clinical Trial. J Oral Implantol 1 December 2022; 48 (6): 541–549. doi: https://doi.org/10.1563/aaid-joi-D-21-00012
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