A systematic review was designed to investigate the effect of treatment with oral bisphosphonate (BP) on osseointegration of dental implants and the incidence of BP-related osteonecrosis of the jaw (BRONJ) in postmenopausal women. Multiple electronic databases, including MEDLINE (PubMed), EMBASE, and SCOPUS, were searched to find all eligible articles published since 1990. All titles and abstracts retrieved by searching information sources were evaluated independently by 2 authors against the eligibility criteria. The number of cases ranged from 11 to 235, and the number of controls ranged from 14 to 343. Alendronate was used in all other studies. Risedronate was used in 6 studies, while ibandronate was used in 4 studies. The number of implants in cases ranged from 25 to 1267, while in controls, the number of implants ranged from 28 to 1450. The time between the placement of implant and the follow-up visit ranged from 4–6 months to 8 years. The results show that out of 2582 placed implants, 50 (1.94%) failed in BP-treated patients. This is while out of 4050 placed implants, 188 (4.6%) failed in the non-BP group. The results from the meta-analysis demonstrated that BP therapy is significantly associated with increased implant failure rates (RR = 1.73 [95% CI, 1.03–2.83], P = .04). Overall, the qualitative assessment of this review suggests that oral treatment with BPs in postmenopausal women does not increase the rate of dental implant failure. Thus, further studies with larger sample sizes should compare BP and non-BP groups in regard to dental implants.
Skip Nav Destination
Article navigation
June 2024
SYSTEMATIC REVIEW|
June 06 2024
Dental Implant Failure in Post-Menopausal Women on Oral Bisphosphonates: A Systematic Review and Meta-Analysis
Bahar Pishan, Msc;
Bahar Pishan, Msc
1Clinical Division of Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria
Search for other works by this author on:
Oleh Andrukhov, PhD;
Oleh Andrukhov, PhD
2Competence Center for Periodontal Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria
Search for other works by this author on:
Xiaohui Rausch-Fan, MD, DDS, PhD
Xiaohui Rausch-Fan, MD, DDS, PhD
*
1Clinical Division of Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria
2Competence Center for Periodontal Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria
*Corresponding author, e-mail: [email protected]
Search for other works by this author on:
J Oral Implantol (2024) 50 (3): 288–295.
Citation
Bahar Pishan, Oleh Andrukhov, Xiaohui Rausch-Fan; Dental Implant Failure in Post-Menopausal Women on Oral Bisphosphonates: A Systematic Review and Meta-Analysis. J Oral Implantol 1 June 2024; 50 (3): 288–295. doi: https://doi.org/10.1563/aaid-joi-D-23-00069
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your Institution
452
Views
1
Web of Science
Citing articles via
Mucosal Coverage of Deeply Protruded Implant in The Maxillary Sinus: A Case Report
Won-Bae Park, DMD, PhD, Joshua Lin, DDS, Wonhee Park, DDS, PhD, Ji-Young Han, DMD,PhD, Philip Kang, DDS
Technique to Protect the Palatal Donor Area After Taking a Free Gingival Graft: Patchwork Technique
Martín Laguna-Martos, DDS, Rocío Cascos, DDS, Óscar Iglesias-Velázquez, DDS, Miguel Gómez-Polo, DDS, PhD, Solange Vasquez-Ramos, DDS, MSD, Adriana Castro-Calderón, DDS
Management of dental implant components following abutment screw loosening: A case report
Chandur Wadhwani, BDS, MSD, Shi Yin, DDS MS, Scott Froum, DDS CTN, Hanson Fong, PhD, Kwok-Hung Chung, DDS MS PhD
Application of Fixed Implant Superstructures following Multi- Stage Maxillary Reconstruction in Osteosarcoma Patients: A case report
Sho Miyamoto, DDS PhD, Hironari Dehari, DDS PhD, Takaaki Tokura, DDS PhD, Takanori Sasaki, DDS PhD, Tomohiro Igarashi, DDS PhD, Shunichi Shimura, DDS PhD, Koyo Nishiyama, DDS PhD, Kenya Mori, DDS, Takatoshi Yotsuyanagi, MD PhD, Akihiro Miyazaki, DDS PhD
Stress Distribution Analysis in Bone Adjacent to Implant in Various Abutment-Implant Connection Designs Using Finite Element Analysis
Ehsan Ghasemi, MSc, Amirhossein Fathi, DDS, MSc, Daryoush Mohammadi, DDs, Sepideh Salehi, DDs