Cemento-osseous dysplasia (COD) is a benign fibro-osseous pathology in which fibrous connective tissues, osteoid and cementum-like materials, replace bone. Concerning the hypovascularization and increased mineralization of bone that occurs in these patients, the clinician may face 2 types of problems: infectious complications, such as osteomyelitis, and increased implant failure. The present study aims to report the successful and innovative management of a COD patient complicated by mandibular osteomyelitis and the implant rehabilitation of this area. We report the management of a 54-year-old patient presenting with florid cemento-osseous dysplasia complicated by mandibular osteomyelitis, which required antibiotic administration and 2 surgeries to resolve. This area was then reconstructed with guided bone regeneration before 3 implants were placed using guided surgery, including 1 implant in a dysplastic area and 1 in the graft site. Osseointegration of the implants allowed rehabilitation with a supraimplant bridge. An optimal functional rehabilitation and complete integration of implants were observed 13 months after the surgery. Eight cases of implant placement in COD patients have been reported before in the literature (n = 35 implants). The success rate of dental implants in nondysplastic areas is comparable to the general population, but it decreases when implants are placed in dysplastic areas. Guided implant surgery is an interesting tool for placing implants outside dysplastic regions.

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