Maxillary defects resulting from oncologic resection pose significant challenges for oral rehabilitation, affecting function, aesthetics, and quality of life. Traditional implant-based solutions are often unfeasible due to insufficient bone volume, necessitating alternative approaches. This case report presents a 54-year-old male who underwent a total maxillectomy for palatal squamous cell carcinoma, followed by chemoradiotherapy. A customized subperiosteal titanium maxillary implant (CSTMI) was designed using virtual surgical planning (VSP), stereolithographic (STL) models, and CAD/CAM technology. The CSTMI framework, incorporating endosseous implants, was secured to the orbital rims and pterygoid plates to optimize prosthetic stability and load distribution. The healing of the patient was uneventful, with no signs of inflammation or dehiscence. The prosthesis improved speech, swallowing, and oral function, significantly enhancing quality of life. At the one-year follow-up, minor screw loosening was successfully managed without complications. CSTMI represents a viable alternative for maxillary reconstruction in patients unsuitable for traditional implants, providing functional and aesthetic rehabilitation. Digital workflows, including VSP and CAD/CAM, are crucial for treatment precision. Long-term studies are needed to assess implant survival, biomechanical optimization, and clinical success.

2025
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