The aim of this study was to evaluate the effect of autogenous tooth bone graft (ATBG) combined with platelet-rich fibrin (PRF) on bone healing in rabbit peri-implant osseous defects. Eighteen New Zealand rabbits were divided into 3 groups. Bone defects were prepared in each rabbit, and then an implant cavity was created in the defects. Dental implants were placed, and the peri-implant bone defects were treated with the following three methods: no graft material was applied in the control group; bone defects were treated with ATBG in the ATBG group; and bone defects were treated with ATBG combined with PRF in the ATBG+PRF group. After 28 days, the rabbits were sacrificed, and the dental implants with surrounding bone were removed. New bone formation and the percentage of bone-to-implant contact (BIC) were determined with histomorphometric evaluations. New bone formation was significantly higher in the ATBG+PRF group compared with the control and ATBG groups (P<0.05). In addition, BIC was significantly higher in the ATBG+PRF group than in the control and ATBG groups (P<0.05). ATBG combined with PRF contributed to bone healing in rabbits with peri-implant bone defects.

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