The aim of this study was to compare the bone regeneration in the anterior maxilla between bone substitutes and autologous platelet concentrate in alveolar ridge preservation.Forty patients requiring tooth extraction in anterior maxilla were randomly allocated to the four following treatment modalities: spontaneous healing (control), natural bovine bone mineral covered with resorbable native collagen membrane (BBM/CM), freeze-dried bone allograft covered with resorbable native collagen membrane (FDBA/CM) and Plasma Rich in Growth Factors alone (PRGF). Bone biopsies and histomorphometrical analysis were performed after 3 months of healing. The following parameters were assessed: newly formed mineralized tissue, the newly formed non-mineralized tissue, and the residual bone grafting material (if applicable). Statistical analysis was performed for descriptive analysis and to compare the parameters of the bone regeneration between the study groups. Histomorphometrical analysis revealed the highest new mineralized tissue formation in PRGF group. Statistically significant differences in new mineralized tissue formation were found between control/PRGF (46.4±15.2% vs 75.5±16.3%), control/(BBM/CM) (46.4±15.2% vs 20.3±21.9%), control/(FDBA/CM) (46.4±15.2% vs 7.2±8.6), PRGF/(BBM/CM) (75.5±16.3 vs 20.3±21.9%), and PRGF/(FDBA/CM) (75.5±16.3 vs 7.2±8.6) groups. The new mineralized tissue formation was in the following order: PRGF > control > BBM>FDBA. Alveolar ridge preservation in aesthetic zone with PRGF has been the most effective in bone regeneration of the alveolar ridge.

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