We hypothesized that in the long-term (6-months follow-up), non-surgical mechanical debridement (NSMD) with adjunct low-level laser therapy (LLLT) is more effective for the treatment of peri-implantitis compared with NSMD alone. The aim of the present 6-months follow-up convenience-sampled cohort study was to assess the efficacy of LLLT as an adjunct to NSMD in the treatment of peri-implantitis. A questionnaire was used to collect demographic information. Patients with peri-implantitis in the test-and control groups underwent NSMD with and without adjunct LLLT, respectively. Randomization was done by tossing a coin. In the test group, the laser was applied perpendicularly to the periodontal pocket for 20 seconds at a constant distance of 15 mm and with a continuous wavelength (3.41 J/cm2 delivery with a 1.76 cm2 spot and average output of 0.3 W). In both groups, peri-implant probing depth, bleeding upon probing and crestal bone resorption were assessed at baseline and at 3- and 6-months’ follow-up. Group comparisons were performed and P<0.05 was considered statistically significant. Sixty-seven individuals with peri-implantitis were included. The mean age of individuals that underwent NSMD with adjunct LLLT and NSMD alone 46.5±3.4 and 45.3±1.1 years, respectively. At 3 and 6-months’ follow-up, peri-implant PI (P<0.05), BUP (P<0.05) and PrD (P<0.05) were significantly higher among patients that underwent NSMD alone compared with individuals that underwent NSMD with adjunct LLLT. There was no significant difference in CBR in all patients up to 6-months’ follow-up. In the short-term, NSMD with adjunct LLLT is a useful treatment protocol for the treatment of peri-implant soft-tissue inflammation.

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