In order to preserve alveolar bone thickness and width after extraction, clinical strategies have been adopted to reduce or eliminate the need for future surgical interventions to increase the alveolar ridge. The use of xenogeneic biomaterials has been increasing for such application. The association of bone substitutes with active oxygen-based materials, which is essential in the wound healing process, could accelerate the bone repair, optimizing the maintenance of alveolar architecture after extraction. However, the truth of this hypothesis is not clear. The present study aimed to compare the biological response to inorganic bovine bone graft Bonefill® (BF), associated or not with active oxygen-based gel Oral gel Blue ® m (BF+BM), in alveolar bone repair. Twenty female Wistar rats were randomly distributed, the left upper central incisor was extracted and the dental sockets were filled with BF in the control group (n=10), and with BF+BM in the experimental group (n=10). After 7- and 42-days’ post implantation (n=5), the animals were euthanized, and the samples were processed for descriptive histological and histomorphometric evaluations. The results showed no significant difference between the groups (p>0.05). Both groups presented a time-dependent increase of new formed bone and biosorption biomaterial (p=0.0001). While the biomaterial analyzed was considered compatible and osteoconductive, the association with Blue ® m gel did not improve or interfere with the bone repair after the experimental periods.

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