Introduction This study aimed to assess the effect of slice thickness of 3D printer in fabrication of surgical guide (SG) on the accuracy of dental implant placement. Materials and Methods After preparation of two dry human mandibles, Cone-beam computed tomography (CBCT) scans were obtained, and the location and direction of implants in the edentulous ridge of the mandible were identified using Romexis software. Data in STL format were transferred to a 3D printer and two SGs with 50 µm and 100 µm thicknesses were fabricated for each mandible. Drilling was performed using two SGs. The pre- and post-intervention CBCT scans were superimposed to measure the magnitude of differences. The two groups were compared using the Mann-Whitney U test. Results No significant difference was noted in SGs with 50 and 100 µm thicknesses in the coronal and apical regions of the implants or the depth of drilling. However, the difference in angular deviation was statistically significant. Conclusion Considering the higher accuracy of SGs with 50 µm thickness (despite the presence of a significant difference in AD between the SGs with different thicknesses), it is recommended to use a SG with 50 µm thickness in cases where anatomical limitations exist.

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