Medication-related osteonecrosis of the jaw (MRONJ) is a serious concern for dentists as well as maxillofacial surgeons. Therefore, the safety of dental implant placement in patient receiving antiresorptive drugs (ARDs) has been the subject of controversial debate for several years and remains a source of uncertainty for surgeons and patients. This consecutive case series assessed the clinical and radiographic outcomes of dental implants placed in patients under antiresorptive therapy. Patients who received at least one dental implant at the Department of Oral and Maxillofacial Surgery, Ludwig Maximilian University (LMU), Munich, Germany, between 2010 and 2019 with a history of current or past antiresorptive medication were included the study. The main outcomes were occurrence of MRONJ, implant success, and survival rate. A total of 16 patients were treated with 39 implants. No implant loss or MRONJ occurred in the respective patients. The reasons for antiresorptive intake were osteoporosis, malignancy, edema of bone marrow, or diffuse sclerosing osteomyelitis (DSO). MRONJ occurred neither around implants nor in other locations. Cumulative implant success was 92.6% (25 of 27). No subjective complaints or postoperative complications were documented. Mean bone loss was 0.60 ± 0.98 mm. The prevalence of peri-implantitis was 30% on patient level and 29.6% on implant level. None of the patients had failed implants. No major complications after implant placement under antiresorptives could be detected. As long as implant surgery follows a specific protocol, implant placement in patients treated with antiresorptive therapy seems to be safe and predictable.
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February 2023
CLINICAL|
April 21 2022
Clinical and Radiographic Outcomes of Dental Implants in Patients Treated With Antiresorptive Drugs: A Consecutive Case Series
Sven Otto, MDS, DDS;
Sven Otto, MDS, DDS
*
1Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University, Munich, Germany.
2Institute for Musculoskeletal Medicine (IMM), Munich, Germany.
*Corresponding author, e-mail: otto_sven@web.de
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Eva Maria Schnoedt, DDS;
Eva Maria Schnoedt, DDS
1Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University, Munich, Germany.
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Matthias Troeltzsch, MD, DDS;
Matthias Troeltzsch, MD, DDS
1Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University, Munich, Germany.
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Gabriele Kaeppler, DDS;
Gabriele Kaeppler, DDS
3Dental Radiology, Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University, Munich, Germany.
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Suad Aljohani, DDS, MSc, PhD;
Suad Aljohani, DDS, MSc, PhD
1Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University, Munich, Germany.
4Department of Oral Diagnostic Sciences, Division of Oral Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
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Anja Liebermann, DDS;
Anja Liebermann, DDS
5Department of Prosthetic Dentistry, Ludwig-Maximilians-University, Munich, Germany.
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Riham Fliefel, DDS, MSc, PhD
Riham Fliefel, DDS, MSc, PhD
1Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University, Munich, Germany.
2Institute for Musculoskeletal Medicine (IMM), Munich, Germany.
6Musculoskeletal University Center (MUM), Munich, Germany.
7Department of Oral and Maxillofacial Surgery, Alexandria University, Alexandria, Egypt.
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J Oral Implantol (2023) 49 (1): 39–45.
Citation
Sven Otto, Eva Maria Schnoedt, Matthias Troeltzsch, Gabriele Kaeppler, Suad Aljohani, Anja Liebermann, Riham Fliefel; Clinical and Radiographic Outcomes of Dental Implants in Patients Treated With Antiresorptive Drugs: A Consecutive Case Series. J Oral Implantol 1 February 2023; 49 (1): 39–45. doi: https://doi.org/10.1563/aaid-joi-D-21-00035
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