The purpose of this case report is to present on implant-retained maxillary and mandibular complete overdentures in a patient with Marfan Syndrome. The patient initially presented with Generalized Periodontitis (Stage IV, Grade C). Due to the progressive nature of periodontal disease in this patient, the patient elected to have implant-retained maxillary and mandibular complete dentures. Bilateral maxillary sinus augmentation was performed six months prior to full mouth extraction, alveoloplasty, and immediate implant placement. Maxillary and Mandibular immediate overdentures were delivered. After 4 months of healing, the final overdenture was fabricated. The patient was seen regularly throughout the healing process for peri-implant maintenance. Soft tissue grafts were completed to increase the thickness of the mucosa around the implants. The patient has been followed for two years and is functioning well without major complications. For patients with Marfan syndrome, implant-retained prostheses are a viable treatment option in the presence of a failing dentition.