Here,we report an inhibitory effect of a sesquiterpene lactone dehydroleucodine (DhL) on the growth of Trypanosoma cruzi in culture. At concentrations of the drug between 5 and 10 µg/ml in the medium,the parasites remained alive for at least 4 days. Higher concentrations of DhL were lethal for the parasites within a few hours. The effect of DhL is irreversible. Morphological changes induced by DhL were also observed in the parasites. The effect of DhL was blocked by the presence of reducing substrates such as glutathione or dithiothreitol, but these agents were not able to reverse the effect of DhL if added 2 days after the start of drug exposure.
THE SESQUITERPENE LACTONE DEHYDROLEUCODINE (DhL) AFFECTS THE GROWTH OF CULTURED EPIMASTIGOTES OF TRYPANOSOMA CRUZI
†We dedicate this paper to the memory of Dr. E. Guerreiro who died on 20 October 1998.
- Views Icon Views
- Share Icon Share
- Search Site
Silvia D. Brengio, Silvia A. Belmonte, Eduardo Guerreiro, Oscar S. Giordano, Elisa O. Pietrobon, Miguel A. Sosa; THE SESQUITERPENE LACTONE DEHYDROLEUCODINE (DhL) AFFECTS THE GROWTH OF CULTURED EPIMASTIGOTES OF TRYPANOSOMA CRUZI. J Parasitol 1 April 2000; 86 (2): 407–412. doi: https://doi.org/10.1645/0022-3395(2000)086[0407:TSLDDA]2.0.CO;2
Download citation file: