The genetic influence on host susceptibility to Neodiplostomum seoulense infection and fatality of the host was studied in 3 inbred strains of mice (BALB/c [H-2d], C3H/He [H-2k], and C57BL/6 [H-2b]). The survival of the mice, worm expulsion kinetics, worm size, number of eggs produced per day (EPD), and number of uterine eggs were observed from day 1 to day 40 postinfection (PI) with 100 or 200 metacercariae per mouse. Infection with N. seoulense was highly lethal to all 3 strains of mice, but the lethality was dose-dependent and varied according to the genetic backgrounds of the mice. The C3H/He mice exhibited the highest mortality, the lowest worm burdens and EPD, and the quickest expulsion of worms. It is suggested that different genetic backgrounds of mice appear to affect the host's capacity to expel N. seoulense and the fatality of the hosts themselves.
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October 2000
Research Article|
October 01 2000
Genetic Difference in Susceptibility and Fatality of Three Strains of Mice Experimentally Infected with Neodiplostomum seoulense
J-Y. Chai;
J-Y. Chai
aDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea
cauthor for correspondence
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E-H. Shin;
E-H. Shin
aDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea
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E-T. Han;
E-T. Han
aDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea
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S-M. Guk;
S-M. Guk
bDepartment of Parasitology, Yonsei University College of Medicine, Seoul 120-752, Korea
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M-H. Choi;
M-H. Choi
aDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea
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S-H. Lee
S-H. Lee
aDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea
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J Parasitol (2000) 86 (5): 1140–1144.
Citation
J-Y. Chai, E-H. Shin, E-T. Han, S-M. Guk, M-H. Choi, S-H. Lee; Genetic Difference in Susceptibility and Fatality of Three Strains of Mice Experimentally Infected with Neodiplostomum seoulense. J Parasitol 1 October 2000; 86 (5): 1140–1144. doi: https://doi.org/10.1645/0022-3395(2000)086[1140:GDISAF]2.0.CO;2
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