Canine red blood cell-substituted severe combined immune deficiency (Ca-RBC-SCID) mice were prepared for canine Babesia gibsoni infection. The Ca-RBC-SCID mice infected with B. gibsoni developed a high level of parasitemia, and showed clinical symptoms such as anemia and hemoglobinuria, which are similar to those observed in dogs infected with B. gibsoni. The B. gibsoni parasites grown in Ca-RBC-SCID mice showed marked morphological changes, including a significantly larger size of parasites than those in dogs and abundant RBCs containing 4, 8, 16, and 32 parasites. The multiple infection may have resulted from 1 parasite because the posterior end of each parasite in a multiply infected cell was connected. The parasites grown in SCID mice retained their infectivity and virulence to dogs and their morphology was dramatically restored to the original state when they were returned to dogs.
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October 2000
FUNCTIONAL MORPHOLOGY|
October 01 2000
MORPHOLOGICAL CHANGES OF BABESIA GIBSONI GROWN IN CANINE RED BLOOD CELL-SUBSTITUTED SEVERE COMBINED IMMUNE DEFICIENCY MICE
Shinya Fukumoto;
Shinya Fukumoto
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Xuenan Xuan;
Xuenan Xuan
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Ikuo Igarashi;
Ikuo Igarashi
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Shoufa Zhang;
Shoufa Zhang
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Jennifer Mugisha;
Jennifer Mugisha
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Takashi Ogata;
Takashi Ogata
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Hideyuki Nagasawa;
Hideyuki Nagasawa
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Kozo Fujisakim;
Kozo Fujisakim
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Naoyoshi Suzuki;
Naoyoshi Suzuki
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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Takeshi Mikami
Takeshi Mikami
The National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
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J Parasitol (2000) 86 (5): 956–959.
Citation
Shinya Fukumoto, Xuenan Xuan, Ikuo Igarashi, Shoufa Zhang, Jennifer Mugisha, Takashi Ogata, Hideyuki Nagasawa, Kozo Fujisakim, Naoyoshi Suzuki, Takeshi Mikami; MORPHOLOGICAL CHANGES OF BABESIA GIBSONI GROWN IN CANINE RED BLOOD CELL-SUBSTITUTED SEVERE COMBINED IMMUNE DEFICIENCY MICE. J Parasitol 1 October 2000; 86 (5): 956–959. doi: https://doi.org/10.1645/0022-3395(2000)086[0956:MCOBGG]2.0.CO;2
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