In Ascaris suum, muscle glycogen is synthesized during host feeding intervals and degraded during nonfeeding intervals. Glycogen accumulation is up to 12-fold greater than that observed in mammalian muscle. Previous studies have established that many aspects of the parasite glycogen metabolism are comparable with the host, but a novel form of glycogen synthase designated GSII also occurs in the parasite. In this report glycogenin has been identified as the core protein in both mature glycogen and the GSII complex. Digestion of GSII complex glycogen generates discreet intermediates that may correspond to a proglycogen pool, whereas digestion of mature glycogen does not generate these intermediates. Because both GSII complex glycogen and mature glycogen serve as GSII substrates, the GSII complex likely represents an intermediate between glycogenin and mature glycogen. The regulation of glycogenin synthesis or the regulation of GSII activity that converts glycogenin to proglycogen, or both, may account for high levels of polysaccharide accumulation that are essential for A. suum survival.
Skip Nav Destination
Article navigation
December 2000
BIOCHEMISTRY-PHYSIOLOGY|
December 01 2000
GLYCOGENIN-DEPENDENT ORGANIZATION OF ASCARIS SUUM MUSCLE GLYCOGEN
Ruthann A. Masaracchia;
Ruthann A. Masaracchia
Department of Biological Sciences, University of North Texas, Denton, Texas 76203
Search for other works by this author on:
Martti R. Rantala;
Martti R. Rantala
Department of Biological Sciences, University of North Texas, Denton, Texas 76203
Search for other works by this author on:
Manus J. Donahue
Manus J. Donahue
Department of Biological Sciences, University of North Texas, Denton, Texas 76203
Search for other works by this author on:
J Parasitol (2000) 86 (6): 1206–1212.
Citation
Ruthann A. Masaracchia, Martti R. Rantala, Manus J. Donahue; GLYCOGENIN-DEPENDENT ORGANIZATION OF ASCARIS SUUM MUSCLE GLYCOGEN. J Parasitol 1 December 2000; 86 (6): 1206–1212. doi: https://doi.org/10.1645/0022-3395(2000)086[1206:GDOOAS]2.0.CO;2
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your Institution
0
Views
1
Crossref
Citing articles via
SEROPREVALENCE OF TOXOPLASMA GONDII AND ASSOCIATED RISK FACTORS IN ONE-HUMPED CAMELS (CAMELUS DROMEDARIUS) IN QATAR
Sonia Boughattas, Hashim Alhussain, Ahmed Gawish, Nahla O. Eltai
SCOLICIDAL POTENCY OF BILE AGAINST ECHINOCOCCUS GRANULOSUS
İsa Caner Aydın, Noyan İlhan, Ahmet Şeker, Cem Batuhan Ofluoğlu, Fırat Mülküt, Nuri Emrah Göret, Kenan Çetin, Erdal Polat, Gökhan Aygün, Hasan Fehmi Kücük
SYNONYMIZATION OF PLACOBDELLA PICTA (VERRILL, 1872) (HIRUDINEA: GLOSSIPHONIIDAE) WITH DESCRIPTIONS OF TWO NEW SPECIES REVEALED BY MOLECULAR SPECIES DELIMITATION
Anna J. Phillips, Dennis J. Richardson, Charlotte I. Hammond, Brett C. Gonzalez, Eric A. Lazo-Wasem, William E. Moser
A RE-EVALUATION OF ZYGOCOTYLE (DIGENEA, PARAMPHISTOMOIDEA) BASED ON NEW GENETIC DATA SUPPORTS ITS SYNONYMIZATION WITH WARDIUS
Tyler J. Achatz, Dawn W. Cleveland, Sarah A. Orlofske, Robert C. Jadin, Jason Block, Lisa K. Belden, Hudson A. Pinto, Vasyl V. Tkach
DESCRIPTION OF A NEW SPECIES OF GYRINICOLA YAMAGUTI, 1938, FROM THE MONTEZUMA FROG, RANA MONTEZUMAE, IN THE TRANSITION ZONE BETWEEN THE NEARCTIC AND NEOTROPICS
Matthew A. Walker, Rogelio Aguilar-Aguilar, Virginia León-Règagnon, F. Agustín Jiménez