Intraspecific heterogeneity was demonstrated in the mini-exon gene localization from Leishmania (Viannia) panamensis and L. (Viannia) guyanensis. Different karyotypes were detected in human isolates circulating in endemic areas of Colombia. The presence of mini-exon gene sequences on chromosomes of different sizes, ranging from 370 to 800 kb in L. (V.) panamensis and from 500 to 800 kb in L. (V.) guyanensis, was observed and was neither strain nor species specific. In some cases, hybridization with 2 chromosomes in the same strain was observed. The variability of chromosomal localization of mini-exon gene sequences of these 2 species highlights the genetic variability of the Viannia subgenus and the potential utility of the mini-exon gene as a molecular epidemiologic marker.
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December 2000
GENETICS-EVOLUTION|
December 01 2000
INTRASPECIFIC HETEROGENEITY IN THE MINI-EXON GENE LOCALIZATION OF LEISHMANIA (VIANNIA) PANAMENSIS AND LEISHMANIA (VIANNIA) GUYANENSIS FROM COLOMBIA Available to Purchase
Raquel S. Pacheco;
Raquel S. Pacheco
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
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Octavio Fernandes;
Octavio Fernandes
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
*Department of Tropical Medicine, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, RJ, Brazil; and Department of Pathology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
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Graciela Salinas;
Graciela Salinas
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
†Centro Internacional de Investigaciones Medicas, CIDEIM, Cali, Colombia.
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Iris Segura;
Iris Segura
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
†Centro Internacional de Investigaciones Medicas, CIDEIM, Cali, Colombia.
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Hooman Momen;
Hooman Momen
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
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Wim Degrave;
Wim Degrave
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
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Nancy G. Saravia;
Nancy G. Saravia
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
†Centro Internacional de Investigaciones Medicas, CIDEIM, Cali, Colombia.
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David A. Campbell
David A. Campbell
Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fiocruz. Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
‡Department of Microbiology and Immunology, University of California, Los Angeles, California 90024.
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J Parasitol (2000) 86 (6): 1250–1253.
Citation
Raquel S. Pacheco, Octavio Fernandes, Graciela Salinas, Iris Segura, Hooman Momen, Wim Degrave, Nancy G. Saravia, David A. Campbell; INTRASPECIFIC HETEROGENEITY IN THE MINI-EXON GENE LOCALIZATION OF LEISHMANIA (VIANNIA) PANAMENSIS AND LEISHMANIA (VIANNIA) GUYANENSIS FROM COLOMBIA. J Parasitol 1 December 2000; 86 (6): 1250–1253. doi: https://doi.org/10.1645/0022-3395(2000)086[1250:IHITME]2.0.CO;2
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