Cryptosporidium parvum is an intracellular protozoan parasite that causes enteric infection and diarrhea in a wide range of mammalian hosts, including humans and economically important livestock species. There are no effective vaccines or drug treatments available for cryptosporidiosis. Cryptosporidium parvum utilizes a unique metabolic pathway for the synthesis of polyamines, forming agmatine as an intermediary metabolite. We treated infant mice with oral doses of agmatine for 2 days before, the day of, and 5 days following experimental infection with C. parvum. Mice treated with agmatine were significantly less infected with C. parvum than were control mice receiving phosphate-buffered saline. Mice treated with agmatine only on the day of experimental infection with C. parvum were also significantly less infected than were control mice. These data suggest that exogenous agmatine alters the metabolism of C. parvum sufficient to interfere with its ability to colonize the mammalian intestine.
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February 2001
THERAPEUTICS-DIAGNOSTICS|
February 01 2001
TREATMENT WITH AGMATINE INHIBITS CRYPTOSPORIDIUM PARVUM INFECTION IN INFANT MICE
Danielle Moore;
Danielle Moore
Veterinary Medical Research Institute, Iowa State University, Ames, Iowa 50011
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W. Ray Waters;
W. Ray Waters
Veterinary Medical Research Institute, Iowa State University, Ames, Iowa 50011
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Michael J. Wannemuehler;
Michael J. Wannemuehler
Veterinary Medical Research Institute, Iowa State University, Ames, Iowa 50011
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James A. Harp
James A. Harp
Veterinary Medical Research Institute, Iowa State University, Ames, Iowa 50011
*U.S. Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Periparturient Diseases of Cattle Research Unit, Ames, Iowa 50010.
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J Parasitol (2001) 87 (1): 211–213.
Citation
Danielle Moore, W. Ray Waters, Michael J. Wannemuehler, James A. Harp; TREATMENT WITH AGMATINE INHIBITS CRYPTOSPORIDIUM PARVUM INFECTION IN INFANT MICE. J Parasitol 1 February 2001; 87 (1): 211–213. doi: https://doi.org/10.1645/0022-3395(2001)087[0211:TWAICP]2.0.CO;2
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