To characterize the extent of genetic diversity of Schistosoma haematobium within and among its definitive host (intra- and interhost parasite diversity), 133 individual isolates from 25 infected schoolchildren were compared using randomly amplified polymorphic DNA markers. With 4 primers, 53 unambiguous loci were identified, and of these, 22 were polymorphic. Mean heterozygosity in the population was 0.116 ± 0.043. Analysis of molecular variance showed the majority of variance occurred within, rather than between, hosts. Frequencies of certain alleles segregated the parasite population into 13 distinct clusters of associated genotypes, with 4 of these first appearing 10 mo after the initial survey. Considering the level of diversity within this limited geographical area and the possibility of rapid turnover of genotypes, parasite variance may impact acquired immunity and clinical outcome of the infection.
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August 2001
GENETICS-EVOLUTION|
August 01 2001
Genetic Diversity of a Population of Schistosoma Haematobium Derived from Schoolchildren in East Central Zimbabwe
Kimberly C. Brouwer;
Kimberly C. Brouwer
The W. Harry Feinstone Department of Molecular Microbiology & Immunology, School of Hygiene and Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, Maryland 21205
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Patricia Ndhlovu;
Patricia Ndhlovu
The W. Harry Feinstone Department of Molecular Microbiology & Immunology, School of Hygiene and Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, Maryland 21205
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Anderson Munatsi;
Anderson Munatsi
The W. Harry Feinstone Department of Molecular Microbiology & Immunology, School of Hygiene and Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, Maryland 21205
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Clive J. Shiff
Clive J. Shiff
The W. Harry Feinstone Department of Molecular Microbiology & Immunology, School of Hygiene and Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, Maryland 21205
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J Parasitol (2001) 87 (4): 762–769.
Citation
Kimberly C. Brouwer, Patricia Ndhlovu, Anderson Munatsi, Clive J. Shiff; Genetic Diversity of a Population of Schistosoma Haematobium Derived from Schoolchildren in East Central Zimbabwe. J Parasitol 1 August 2001; 87 (4): 762–769. doi: https://doi.org/10.1645/0022-3395(2001)087[0762:GDOAPO]2.0.CO;2
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