Adenosine and AMP in the salivary glands of the sand fly Phlebotomus argentipes were characterized by reversed-phase high-pressure liquid chromatography with diode-array detection and mass spectrometry. AMP and adenosine were measured in individual salivary gland pairs, yielding 76.8 ± 8.6 and 380 ± 25 pmoles per pair of salivary glands, respectively (mean ± SE, n = 12). These values decrease to 45 ± 7 and 181 ± 21 pmoles following a blood meal, indicating that AMP and adenosine were secreted. Because adenosine and AMP have anti-platelet, vasodilatory, and immunomodulatory properties, it is proposed that these salivary nucleotides help the fly to blood feed and may affect Leishmania transmission.
The Salivary Adenosine/AMP Content of Phlebotomus argentipes Annandale and Brunetti, the Main Vector of Human Kala-Azar
- Views Icon Views
- Share Icon Share
- Search Site
J. M C. Ribeiro, Govind Modi; The Salivary Adenosine/AMP Content of Phlebotomus argentipes Annandale and Brunetti, the Main Vector of Human Kala-Azar. J Parasitol 1 August 2001; 87 (4): 915–917. doi: https://doi.org/10.1645/0022-3395(2001)087[0915:TSAACO]2.0.CO;2
Download citation file: