In Trypanosoma brucei, uptake of host transferrin is mediated by a heterodimeric, glycosylphosphatidylinositol-anchored receptor derived from the 2 expression site–associated genes 6 and 7 (ESAG6 and ESAG7). By using specific antibodies, it is shown here that T. evansi, a trypanosome species transmitted mechanically by biting flies, also expresses a transferrin receptor composed of ESAG6 and ESAG7. The cellular uptake of transferrin in T. evansi is completely inhibited with anti-T. brucei (ESAG6/7 heterodimer) antibodies. The demonstration of a functional ESAG6/7 transferrin receptor in T. evansi supports further its close relationship to T. brucei.
Trypanosoma evansi: Demonstration of a Transferrin Receptor Derived From Expression Site–Associated Genes 6 and 7
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Mostafa Kabiri, Dietmar Steverding; Trypanosoma evansi: Demonstration of a Transferrin Receptor Derived From Expression Site–Associated Genes 6 and 7. J Parasitol 1 October 2001; 87 (5): 1189–1191. doi: https://doi.org/10.1645/0022-3395(2001)087[1189:TEDOAT]2.0.CO;2
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