A strain of Plasmodium vivax from India was adapted to develop in splenectomized Saimiri boliviensis, Aotus lemurinus griseimembra, A vociferans, A. nancymai, A. azarae boliviensis, hybrid Aotus monkeys, and splenectomized chimpanzees. Infections were induced via the inoculation of sporozoites dissected from the salivary glands of Anopheles stephensi and An. dirus mosquitoes to 12 Aotus and 8 Saimiri monkeys; transmission via the bites of infected An. stephensi was made to 1 Aotus monkey and 1 chimpanzee. The intravenous passage of infected erythrocytes was made to 9 Aotus monkeys and 4 chimpanzees. Gametocytes in 13 Aotus monkeys and 4 chimpanzees were infectious to mosquitoes. Infection rates were markedly higher in mosquitoes fed on chimpanzees. PCR studies on 10 monkeys injected with sporozoites revealed the presence of parasites before their detection by microscopic examination. The India VII strain of P. vivax develops in Aotus and Saimiri monkeys and chimpanzees following the injection of parasitized erythrocytes, or sporozoites, or both. The transmission rate via sporozoites to New World monkeys of approximately 50% may be too low for the testing of sporozoite vaccines or drugs directed against the exoerythrocytic stages. However, the strain is highly infectious to commonly available laboratory-maintained anopheline mosquitoes. Mosquito infection is especially high when feedings are made with gametocytes from splenectomized chimpanzees.
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December 2001
LIFE CYCLES-SURVEY|
December 01 2001
ADAPTATION OF A STRAIN OF PLASMODIUM VIVAX FROM INDIA TO NEW WORLD MONKEYS, CHIMPANZEES, AND ANOPHELINE MOSQUITOES
JoAnn S. Sullivan;
JoAnn S. Sullivan
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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Elizabeth Strobert;
Elizabeth Strobert
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
* Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322.
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Chunfu Yang;
Chunfu Yang
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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Carla L. Morris;
Carla L. Morris
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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G. Gale Galland;
G. Gale Galland
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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Bettye B. Richardson;
Bettye B. Richardson
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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Amy Bounngaseng;
Amy Bounngaseng
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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Jesse Kendall;
Jesse Kendall
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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Harold McClure;
Harold McClure
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
* Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322.
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William E. Collins
William E. Collins
Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, Georgia 30341
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J Parasitol (2001) 87 (6): 1398–1403.
Citation
JoAnn S. Sullivan, Elizabeth Strobert, Chunfu Yang, Carla L. Morris, G. Gale Galland, Bettye B. Richardson, Amy Bounngaseng, Jesse Kendall, Harold McClure, William E. Collins; ADAPTATION OF A STRAIN OF PLASMODIUM VIVAX FROM INDIA TO NEW WORLD MONKEYS, CHIMPANZEES, AND ANOPHELINE MOSQUITOES. J Parasitol 1 December 2001; 87 (6): 1398–1403. doi: https://doi.org/10.1645/0022-3395(2001)087[1398:AOASOP]2.0.CO;2
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