C3H/HeN female mice infected with distinct Trypanosoma cruzi subpopulations (RA strain [pantropic/reticulotropic] and K98 clone of the CA-I strain [myotropic]) show differences both in inflammatory compromise of the genital tract and in the outcome of pregnancy. The group of mice infected with the K98 clone show lymphomononuclear infiltrates in pelvian fat and in uterus interstitium, coexisting with the presence of T. cruzi DNA, and show moderate oophoritis, perioophoritis, and vasculitis. However, neither parasite DNA nor inflammatory foci were detected in the uterus, and only mild oophoritis was observed among RA-infected mice at mating time. Independently from the parasite subpopulation, females developed estrous 30 days postinoculation (PI), and at the same time, parasite counts were similar for K98 and for RA-infected mice. However, fertility was significantly diminished in K98-infected females. On day 14 of gestation, fetal resorptions increased in this group and cannot be attributed to hormonal disbalance because similar serum progesterone levels were found in all groups. At this time (44 days PI), parasitemia was higher in K98- than in RA-infected mice. However, resorptions were not triggered by massive infection because polymerase chain reaction failed to prove parasite DNA in resorbing fetuses. In contrast with K98 females, RA-infected mice delivered T. cruzi–infected newborns.
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February 2002
Research Article|
February 01 2002
TRYPANOSOMA CRUZI: EFFECT OF PARASITE SUBPOPULATION ON MURINE PREGNANCY OUTCOME
María Elisa Solana;
María Elisa Solana
Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, (CP 1121) Buenos Aires, Argentina. smgcappa@fmed.uba.ar
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Ana María Celentano;
Ana María Celentano
Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, (CP 1121) Buenos Aires, Argentina. smgcappa@fmed.uba.ar
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Valeria Tekiel;
Valeria Tekiel
Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, (CP 1121) Buenos Aires, Argentina. smgcappa@fmed.uba.ar
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Marta Jones;
Marta Jones
Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, (CP 1121) Buenos Aires, Argentina. smgcappa@fmed.uba.ar
* Servicio de Patología, Sala de Neuropatología, Hospital de Niños “Sor María Ludovica”, La Plata, Argentina.
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Stella Maris González Cappa
Stella Maris González Cappa
Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, (CP 1121) Buenos Aires, Argentina. smgcappa@fmed.uba.ar
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J Parasitol (2002) 88 (1): 102–106.
Citation
María Elisa Solana, Ana María Celentano, Valeria Tekiel, Marta Jones, Stella Maris González Cappa; TRYPANOSOMA CRUZI: EFFECT OF PARASITE SUBPOPULATION ON MURINE PREGNANCY OUTCOME. J Parasitol 1 February 2002; 88 (1): 102–106. doi: https://doi.org/10.1645/0022-3395(2002)088[0102:TCEOPS]2.0.CO;2
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