Trichomonad total extracts (TTE), or vesicular (P30) and soluble (S30) subcellular fractions from 3 pathogenic Trichomonas vaginalis strains (GT-3, GT-13, and GT-15), lysed both human and Sprague–Dawley rat erythrocytes in a time- and dose-dependent manner. The entire hemolytic activity of TTE was located in P30, showing 2 peaks of maximum activity, one at pH 6.0 and another at pH 8.0, in the presence of 1 mM Ca2+. Hemolytic activity on rat erythrocytes was greater at pH 6.0 (6.71 ± 0.33 hemolytic units [HU]/mg/hr to 11.60 ± 0.24 HU/mg/hr) than at pH 8.0 (3.81 ± 0.30 HU/mg/hr to 5.75 ± 0.65 HU/mg/hr), and it was greater than that on human red blood cells at pH 6.0 (2.67 ± 0.19 HU/mg/hr to 4.08 ± 0.15 HU/mg/hr) or pH 8.0 (2.24 ± 0.09 HU/mg/hr to 2.81 ± 0.06 HU/mg/hr). The alkaline and acidic hemolytic activity diminished (60–93% at pH 6.0 and 78–93% at pH 8.0) by the effect of 80 μM Rosenthal's inhibitor, which also inhibited 27–45% and 29–54% trichomonad alkaline and acidic phospholipase A activities, respectively. Vesicles, vacuoles, and hydrogenosomes were rich in P30. Trichomonas vaginalis has a hemolytic PLA, which could be involved in its cytopathogenic mechanism.
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February 2003
Research Article|
February 01 2003
TRICHOMONAS VAGINALIS: IDENTIFICATION OF A PHOSPHOLIPASE A–DEPENDENT HEMOLYTIC ACTIVITY IN A VESICULAR SUBCELLULAR FRACTION
Javier Vargas-Villarreal;
Javier Vargas-Villarreal
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
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Benito D. Mata-Cárdenas;
Benito D. Mata-Cárdenas
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
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Francisco González-Salazar;
Francisco González-Salazar
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
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Héctor G. Lozano-Garza;
Héctor G. Lozano-Garza
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
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Elva I. Cortes-Gutierrez;
Elva I. Cortes-Gutierrez
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
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Rebeca Palacios-Corona;
Rebeca Palacios-Corona
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
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Herminia G. Martínez-Rodríguez;
Herminia G. Martínez-Rodríguez
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
* Unidad de Laboratorios de Ingeniería y Expresión Genética, Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Avenida Madero y José E. González, Apartado Postal 1563, Monterrey, Nuevo León, México
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Enrique Ramírez-Bon;
Enrique Ramírez-Bon
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
† Departamento de Anatomía Patología Facultad de Medicina, Universidad Autónoma de Nuevo León, Avenida Madero y José E. González, Apartado Postal 1563, Monterrey, Nuevo León, México
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Salvador Said-Fernández
Salvador Said-Fernández
División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Administración de Correos No. 4, Apartado Postal 020-E, Colonia Independencia, Monterrey, CP 64720, Nuevo León, México. ssaid@mail.mty.itesm.mx
‡ To whom correspondence should be addressed
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J Parasitol (2003) 89 (1): 105–112.
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Javier Vargas-Villarreal, Benito D. Mata-Cárdenas, Francisco González-Salazar, Héctor G. Lozano-Garza, Elva I. Cortes-Gutierrez, Rebeca Palacios-Corona, Herminia G. Martínez-Rodríguez, Enrique Ramírez-Bon, Salvador Said-Fernández; TRICHOMONAS VAGINALIS: IDENTIFICATION OF A PHOSPHOLIPASE A–DEPENDENT HEMOLYTIC ACTIVITY IN A VESICULAR SUBCELLULAR FRACTION. J Parasitol 1 February 2003; 89 (1): 105–112. doi: https://doi.org/10.1645/0022-3395(2003)089[0105:TVIOAP]2.0.CO;2
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