The importance of B cells in host resistance to, and recovery from, Cryptosporidium parvum infection was examined in gene-targeted B cell–deficient (μMT−/−) mice. Neonatal μMT−/− mice infected with C. parvum at 5 days of age completely cleared the infection by day 20 PI. The kinetics of infection and clearance were similar to those seen with age-matched C57BL/6 control mice. Furthermore, B cells were not required to clear existing C. parvum infection in adult mice. Reconstitution of persistently infected Rag-1−/− adult mice with spleen cells from μMT−/− donor mice resulted in significant reduction of infection, as in the results seen with spleen cells from C57BL6 donors. These findings indicate clearly that B cells are not essential for host resistance to, and recovery from, C. parvum infection in mice.
Cryptosporidium parvum Infection in Gene-Targeted B Cell–Deficient Mice
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Wangxue Chen, James A. Harp, Allen G. Harmsen; Cryptosporidium parvum Infection in Gene-Targeted B Cell–Deficient Mice. J Parasitol 1 April 2003; 89 (2): 391–393. doi: https://doi.org/10.1645/0022-3395(2003)089[0391:CPIIGB]2.0.CO;2
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