Role of intestinal goblet cells (GCs) in the expulsion of Gymnophalloides seoi was studied using 4 strains of mice, ICR, C3H/HeN, BALB/c, and C57BL/6, after infection with 200 metacercariae isolated from oysters. On day 7 postinfection (PI), significantly higher (P < 0.05) worm recovery rates (WRRs) were observed in ICR (29.5 ± 12.0%) and C3H/HeN (14.8 ± 8.2%) than in BALB/c (5.7 ± 5.3%) and C57BL/6 (0.8 ± 1.1%) mice. Alteration of the GC mucins was marked in C57BL/6 mice. On day 14 PI, 5.2 ± 5.2% and 0.6 ± 0.7% of worms were recovered only from ICR and C3H/HeN mice. When C57BL/6 mice were immunosuppressed with prednisolone, WRR on day 7 PI increased to 11.7 ± 13.9%, whereas the GC hyperplasia and mucin alteration diminished significantly. The results suggest that expulsion of G. seoi from the intestine is dependent on immune responses of the host, and GCs may be an important effector.
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October 2003
Research Article|
October 01 2003
Role of Intestinal Goblet Cells in the Expulsion of Gymnophalloides seoi From Mice
M. Seo;
M. Seo
aDepartment of Parasitology, College of Medicine, Dankook University, Chonan 330-714, South Korea
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S-M. Guk;
S-M. Guk
bDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, South Korea
cDepartment of Parasitology, Kwangwon National University, College of Medicine, Chunchon 200-701, South Korea
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E-T. Han;
E-T. Han
bDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, South Korea
cDepartment of Parasitology, Kwangwon National University, College of Medicine, Chunchon 200-701, South Korea
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J-Y. Chai
J-Y. Chai
bDepartment of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, South Korea
cDepartment of Parasitology, Kwangwon National University, College of Medicine, Chunchon 200-701, South Korea
dto whom correspondence should be addressed. cjy@plaza.snu.ac.kr
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J Parasitol (2003) 89 (5): 1080–1082.
Citation
M. Seo, S-M. Guk, E-T. Han, J-Y. Chai; Role of Intestinal Goblet Cells in the Expulsion of Gymnophalloides seoi From Mice. J Parasitol 1 October 2003; 89 (5): 1080–1082. doi: https://doi.org/10.1645/GE-3182RN
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