Tapeworms alter the physiological environment of the host's small intestinal lumen by contracting the intestinal smooth muscle, thereby slowing the transit of intestinal contents. We hypothesize that parasite-to-host molecular signaling is responsible for the specific patterns of small intestinal smooth muscle contraction observed both during tapeworm infection and after the infusion of tapeworm-secreted molecules into the intestinal lumen of unanesthetized rats. Of the tapeworm-secreted compounds tested, only lumenal infusion of guanosine 3′,5′-cyclic monophosphate (cGMP) induced contractile patterns that mimic those observed during tapeworm infection. The response to cGMP occurred in a concentration-dependent fashion. Our study clearly demonstrates that cGMP can serve as an extracellular signal molecule regulating small intestinal motility mechanisms in vivo.
GUANOSINE 3′,5′-CYCLIC MONOPHOSPHATE: A TAPEWORM-SECRETED SIGNAL MOLECULE COMMUNICATING WITH THE RAT HOST'S SMALL INTESTINE
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K. Dubear Kroening, Noah P. Zimmerman, Paul Bass, John A. Oaks; GUANOSINE 3′,5′-CYCLIC MONOPHOSPHATE: A TAPEWORM-SECRETED SIGNAL MOLECULE COMMUNICATING WITH THE RAT HOST'S SMALL INTESTINE. J Parasitol 1 December 2003; 89 (6): 1136–1141. doi: https://doi.org/10.1645/GE-3307
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