Tapeworms alter the physiological environment of the host's small intestinal lumen by contracting the intestinal smooth muscle, thereby slowing the transit of intestinal contents. We hypothesize that parasite-to-host molecular signaling is responsible for the specific patterns of small intestinal smooth muscle contraction observed both during tapeworm infection and after the infusion of tapeworm-secreted molecules into the intestinal lumen of unanesthetized rats. Of the tapeworm-secreted compounds tested, only lumenal infusion of guanosine 3′,5′-cyclic monophosphate (cGMP) induced contractile patterns that mimic those observed during tapeworm infection. The response to cGMP occurred in a concentration-dependent fashion. Our study clearly demonstrates that cGMP can serve as an extracellular signal molecule regulating small intestinal motility mechanisms in vivo.
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December 2003
Research Article|
December 01 2003
GUANOSINE 3′,5′-CYCLIC MONOPHOSPHATE: A TAPEWORM-SECRETED SIGNAL MOLECULE COMMUNICATING WITH THE RAT HOST'S SMALL INTESTINE
K. Dubear Kroening;
K. Dubear Kroening
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102. oaksj@svm.vetmed.wisc.edu
* Biological Sciences, University of Wisconsin–Fox Valley, 1478 Midway Road, Menasha, Wisconsin 54952-1297
‡ School of Pharmacy, University of Wisconsin–Madison, 777 Hyland Avenue, Madison, Wisconsin 53705-2222
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Noah P. Zimmerman;
Noah P. Zimmerman
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102. oaksj@svm.vetmed.wisc.edu
‡ School of Pharmacy, University of Wisconsin–Madison, 777 Hyland Avenue, Madison, Wisconsin 53705-2222
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Paul Bass;
Paul Bass
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102. oaksj@svm.vetmed.wisc.edu
† Although K.D.K. and N.P.Z. are listed alphabetically, both individuals qualify as “first authors” by their equal contributions to the work and intellectual development of data leading to this article
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John A. Oaks
John A. Oaks
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102. oaksj@svm.vetmed.wisc.edu
§ To whom correspondence should be addressed
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J Parasitol (2003) 89 (6): 1136–1141.
Citation
K. Dubear Kroening, Noah P. Zimmerman, Paul Bass, John A. Oaks; GUANOSINE 3′,5′-CYCLIC MONOPHOSPHATE: A TAPEWORM-SECRETED SIGNAL MOLECULE COMMUNICATING WITH THE RAT HOST'S SMALL INTESTINE. J Parasitol 1 December 2003; 89 (6): 1136–1141. doi: https://doi.org/10.1645/GE-3307
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