Interferon-γ (IFN-γ) contributes to host resistance during acute infection with Trypanosoma cruzi, the causative agent of Chagas' disease. Inducibly expressed guanosine triphosphatase (IGTP), a 48-kDa guanosine triphosphatase (GTPase), is a member of a family of GTPase proteins inducibly expressed by IFN-γ. The expression pattern of IGTP suggests that it may mediate IFN-γ–induced responses in a variety of cell types. IGTP has been demonstrated to be important for control of Toxoplasma gondii infection but not for resistance against Listeria monocytogenes. We evaluated the role of IGTP in development of chronic chagasic cardiomyopathy in IGTP null mice and C57X129sv (wild type [WT]) mice infected with the Brazil strain for 6 mo. There was no significant difference in parasitemia or cardiac histopathology between null and WT mice. Right ventricular remodeling was observed in infected IGTP null mice, suggesting that IGTP does not significantly alter the course of T. cruzi infection.
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December 2003
Research Article|
December 01 2003
Absence of Interferon-γ–Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain)
A. P. de Souza
;
A. P. de Souza
aDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461
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B. Tang
;
B. Tang
aDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461
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H. B. Tanowitz
;
H. B. Tanowitz
bDepartment of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, Bronx, New York 10461
cDepartment of Medicine, Divisions of Infectious Diseases and Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461
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S. M. Factor
;
S. M. Factor
bDepartment of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, Bronx, New York 10461
cDepartment of Medicine, Divisions of Infectious Diseases and Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461
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V. Shtutin
;
V. Shtutin
bDepartment of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, Bronx, New York 10461
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J. Shirani
;
J. Shirani
cDepartment of Medicine, Divisions of Infectious Diseases and Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461
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G. A. Taylor
;
G. A. Taylor
dDepartments of Medicine and Immunology and the Center for the Study of Aging and Human Development, Duke University, Durham, North Carolina 27710
eGeriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, North Carolina 27705. jelicks@aecom.yu.edu
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L. M. Weiss
;
L. M. Weiss
bDepartment of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, Bronx, New York 10461
cDepartment of Medicine, Divisions of Infectious Diseases and Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461
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L. A. Jelicks
L. A. Jelicks
aDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461
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J Parasitol (2003) 89 (6): 1237–1239.
Citation
A. P. de Souza, B. Tang, H. B. Tanowitz, S. M. Factor, V. Shtutin, J. Shirani, G. A. Taylor, L. M. Weiss, L. A. Jelicks; Absence of Interferon-γ–Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain). J Parasitol 1 December 2003; 89 (6): 1237–1239. doi: https://doi.org/10.1645/GE-3185RN
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