An in vitro assay to evaluate the bacteriolytic activity of the complement pathway was applied to 2 strains of Borrelia bissettii, CO501 and DN127, and compared with that of B. burgdorferi sensu stricto B31. Sera from mule deer (Odocoileus hemionus) and the Western Fence lizard (Sceloporus occidentalis) were completely borreliacidal for B. burgdorferi and for both strains of B. bissettii. Serum from Bobwhite quail (Colinus virginianus) was nonlytic for B. burgdorferi and partially lytic for B. bissettii strains, CO-501 and DN127. Serum from a New Zealand White rabbit (Oryctolagus cuniculus) was partially lytic for all 3 strains of Borrelia, whereas serum from white-footed mice (Peromyscus leucopus) were nonlytic for all 3 Borrelia strains. The spectrum of complement sensitivity of B. bissettii appears to be similar to that of European B. afzelii in that tested rodent serum is not lytic to these 2 genospecies. Interestingly, both B. bissettii and B. afzelii have been found to be closely associated with rodents. Complement sensitivity demonstrated in these experiments may suggest and possibly predict specific reservoir–host associations.
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December 2003
Research Article|
December 01 2003
Bacteriolytic Activity of Selected Vertebrate Sera for Borrelia burgdorferi Sensu Stricto and Borrelia bissettii
Amy J. Ullmann;
Amy J. Ullmann
aDivision of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522
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Robert S. Lane;
Robert S. Lane
bDepartment of Environmental Science, Policy, and Management, Division of Insect Biology, University of California, Berkeley, California 94720
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Klaus Kurtenbach;
Klaus Kurtenbach
cDepartment of Infectious Disease Epidemiology, Imperial College of Science Technology and Medicine, St. Mary's Campus, Norfolk Place, London W21PG, U.K.
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Michael Miller;
Michael Miller
dColorado Division of Wildlife, Fort Collins, Colorado 80526; To whom correspondence should be addressed. aff1@cdc.gov
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Martin E. Schriefer;
Martin E. Schriefer
aDivision of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522
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Nordin Zeidner;
Nordin Zeidner
aDivision of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522
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Joseph Piesman
Joseph Piesman
aDivision of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522
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J Parasitol (2003) 89 (6): 1256–1257.
Citation
Amy J. Ullmann, Robert S. Lane, Klaus Kurtenbach, Michael Miller, Martin E. Schriefer, Nordin Zeidner, Joseph Piesman; Bacteriolytic Activity of Selected Vertebrate Sera for Borrelia burgdorferi Sensu Stricto and Borrelia bissettii. J Parasitol 1 December 2003; 89 (6): 1256–1257. doi: https://doi.org/10.1645/Ge-3081RN
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