Raccoon roundworms (Baylisascaris procyonis) and other Baylisascaris species cause patent or latent larva migrans (LM) in a variety of mammals and birds, including humans. It is not clear whether LM by Baylisascaris transfuga, roundworms of bears, is associated with clinical neurological disorders. To clarify this issue, ICR and BALB/c mice as well as Mongolian jirds (Meriones unguiculatus) were orally inoculated with 2,000–5,000 embryonated eggs of B. transfuga. In mice, the ascarid caused symptomatic LM of limited extent and duration, whereas the infection was fatal in jirds; i.e., they exhibited general signs such as severe depression and emaciation on days 8–11 postinfection (PI) and died, or they developed progressive and fatal neurological disorders after day 14 PI. Histological examination showed B. transfuga larvae in the brain of all mice and jirds examined, and the larvae collected from them developed to a size comparable with that of B. procyonis. There existed, however, critical differences in host reactions against larvae localized in the brain of mice and jirds; B. transfuga larvae found in mice were surrounded by granulomatous reactions and immobilized, whereas larvae found in jirds were free from any host reaction and mobile, causing extensive malacia.
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August 2004
PATHOLOGY|
August 01 2004
LARVA MIGRANS BY BAYLISASCARIS TRANSFUGA: FATAL NEUROLOGICAL DISEASES IN MONGOLIAN JIRDS, BUT NOT IN MICE
Hiroshi Sato;
Hiroshi Sato
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. sato7dp4@cc.hirosaki-u.ac.jp
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Kayoko Matsuo;
Kayoko Matsuo
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. sato7dp4@cc.hirosaki-u.ac.jp
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Arihiro Osanai;
Arihiro Osanai
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. sato7dp4@cc.hirosaki-u.ac.jp
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Haruo Kamiya;
Haruo Kamiya
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. sato7dp4@cc.hirosaki-u.ac.jp
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Nobuaki Akao;
Nobuaki Akao
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. sato7dp4@cc.hirosaki-u.ac.jp
* Section of Environmental Parasitology, Graduate School of Tokyo Medical and Dental University, Tokyo 113-8519, Japan
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Shigeo Owaki;
Shigeo Owaki
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. sato7dp4@cc.hirosaki-u.ac.jp
† Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan
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Hidefumi Furuoka
Hidefumi Furuoka
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. sato7dp4@cc.hirosaki-u.ac.jp
† Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan
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J Parasitol (2004) 90 (4): 774–781.
Citation
Hiroshi Sato, Kayoko Matsuo, Arihiro Osanai, Haruo Kamiya, Nobuaki Akao, Shigeo Owaki, Hidefumi Furuoka; LARVA MIGRANS BY BAYLISASCARIS TRANSFUGA: FATAL NEUROLOGICAL DISEASES IN MONGOLIAN JIRDS, BUT NOT IN MICE. J Parasitol 1 August 2004; 90 (4): 774–781. doi: https://doi.org/10.1645/GE-3330
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