Spores of Myxobolus pendula develop within the cores of complex cysts on the gill arch of creek chub Semotilus atromaculatus. Adjacent to, and surrounding, the spores are concentric layers of stratified interdigitating cells, whose nature was examined by transmission electron microscopy and by immunohistochemical and molecular biological techniques. In situ hybridization data using parasite-derived ribosomal DNA as a probe indicate that infection leads to the encapsulation of developing plasmodia by host immune cells that form an epithelioid granuloma. Epithelioid cell–cell adhesion is effected by desmosomes anchored intracellularly to cytokeratin intermediate filaments. High levels of alkaline phosphatase activity are associated with regions of cellular interdigitation. The granuloma may serve to limit the spread of the parasite to surrounding tissues but does not appear to inhibit diffusion of oxygen and nutrients to the developing spores.
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December 2004
PATHOLOGY|
December 01 2004
ENCAPSULATION OF MYXOBOLUS PENDULA (MYXOSPORIDIA) BY EPITHELIOID CELLS OF ITS CYPRINID HOST SEMOTILUS ATROMACULATUS
Anne Koehler;
Anne Koehler
Department of Zoology, University of Toronto, Toronto, M5S 3G5 Ontario, Canada. [email protected]
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Patricia Romans;
Patricia Romans
Department of Zoology, University of Toronto, Toronto, M5S 3G5 Ontario, Canada. [email protected]
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Sherwin Desser;
Sherwin Desser
Department of Zoology, University of Toronto, Toronto, M5S 3G5 Ontario, Canada. [email protected]
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Maurice Ringuette
Maurice Ringuette
Department of Zoology, University of Toronto, Toronto, M5S 3G5 Ontario, Canada. [email protected]
* To whom correspondence should be addressed
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J Parasitol (2004) 90 (6): 1401–1405.
Citation
Anne Koehler, Patricia Romans, Sherwin Desser, Maurice Ringuette; ENCAPSULATION OF MYXOBOLUS PENDULA (MYXOSPORIDIA) BY EPITHELIOID CELLS OF ITS CYPRINID HOST SEMOTILUS ATROMACULATUS. J Parasitol 1 December 2004; 90 (6): 1401–1405. doi: https://doi.org/10.1645/GE-3404
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