Tachyzoites of Toxoplasma gondii were located inside the nucleus of both skeletal muscle cells infected in vitro and peritoneal exudate cells collected from infected mouse in vivo. Ultrastructural analysis demonstrated that T. gondii invades the nucleus of host cells by the parasite apical region and with constriction of its body. We noted that the rhoptry, a secretory organelle of the parasite that is involved in the host cell invasion mechanism, was empty in the intranuclear T. gondii. The parasites were found in the nuclear matrix without evidence of the vacuolar membrane. Frequently, new parasites invaded host cell nucleus, which was already infected. The significance of this nuclear invasion could reflect an alternative route of T. gondii for its transitory survival or an escape mechanism from the host immune response during the in vivo infection (or both).
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February 2005
RESEARCH NOTES|
February 01 2005
Absence of Vacuolar Membrane Involving Toxoplasma gondii During Its Intranuclear Localization
H. S. Barbosa;
H. S. Barbosa
aLaboratório de Ultra-estrutura Celular, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil
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M. F. Ferreira-Silva;
M. F. Ferreira-Silva
aLaboratório de Ultra-estrutura Celular, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil
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E. V. Guimarães;
E. V. Guimarães
aLaboratório de Ultra-estrutura Celular, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil
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L. Carvalho;
L. Carvalho
bLaboratório de Cultura de Células, Departamento de Histologia e Embriologia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, 20551-170 Rio de Janeiro, RJ, Brasil. [email protected]
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R. M. Rodrigues
R. M. Rodrigues
aLaboratório de Ultra-estrutura Celular, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil
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J Parasitol (2005) 91 (1): 182–184.
Citation
H. S. Barbosa, M. F. Ferreira-Silva, E. V. Guimarães, L. Carvalho, R. M. Rodrigues; Absence of Vacuolar Membrane Involving Toxoplasma gondii During Its Intranuclear Localization. J Parasitol 1 February 2005; 91 (1): 182–184. doi: https://doi.org/10.1645/GE-276R
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