Hyperimmune anti-Cryptosporidium parvum ovine colostral whey (HOCW) was tested to determine whether it conferred passive immunity to newborn NMRI mice. Three HOCWs (groups IV–VI), 2 nonimmune colostral wheys (groups II and III), and PBS (group I) were administered once (experiment A) and 3 times (experiment B) daily from −1 to 15 days postinfection (PI). Mice in groups I–VI were inoculated with 5 × 105 oocysts (day 0 PI), and group VII mice acted as controls. The percentage and intensity of infection were measured at 6, 9, 12, and 16 days PI. In experiment A, HOCW did not reduce significantly the percentage and intensity of infection except for mice in group VI treated with HOCW with the highest titers of anti-C. parvum antibodies. In contrast, no infection was detected in between 18.7 and 62.5% of the mice in groups IV–VI in experiment B. Furthermore, in these groups, the intensity of the infection decreased significantly, ranging from 83.5 to 97.4%. Thus, HOCW did not completely avoid infection, but a high level of protection was observed, being proportional to the titer of specific antibodies and the amount of whey administered orally. Finally, group VII showed no presence of oocysts.
Skip Nav Destination
Article navigation
June 2005
THERAPEUTICS-DIAGNOSTICS|
June 01 2005
ORAL ADMINISTRATION OF HYPERIMMUNE ANTI–CRYPTOSPORIDIUM PARVUM OVINE COLOSTRAL WHEY CONFERS A HIGH LEVEL OF PROTECTION AGAINST CRYPTOSPORIDIOSIS IN NEWBORN NMRI MICE
S. Martín-Gómez;
S. Martín-Gómez
Department of Sanidad Animal, Faculty of Veterinary, University of León, C/Profesor Pedro Cármenes s/n, 24071 León, Spain. [email protected]
Search for other works by this author on:
M. A. Álvarez-Sánchez;
M. A. Álvarez-Sánchez
Department of Sanidad Animal, Faculty of Veterinary, University of León, C/Profesor Pedro Cármenes s/n, 24071 León, Spain. [email protected]
Search for other works by this author on:
F. A. Rojo-Vázquez
F. A. Rojo-Vázquez
Department of Sanidad Animal, Faculty of Veterinary, University of León, C/Profesor Pedro Cármenes s/n, 24071 León, Spain. [email protected]
* To whom correspondence should be addressed
Search for other works by this author on:
J Parasitol (2005) 91 (3): 674–678.
Citation
S. Martín-Gómez, M. A. Álvarez-Sánchez, F. A. Rojo-Vázquez; ORAL ADMINISTRATION OF HYPERIMMUNE ANTI–CRYPTOSPORIDIUM PARVUM OVINE COLOSTRAL WHEY CONFERS A HIGH LEVEL OF PROTECTION AGAINST CRYPTOSPORIDIOSIS IN NEWBORN NMRI MICE. J Parasitol 1 June 2005; 91 (3): 674–678. doi: https://doi.org/10.1645/GE-3423
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
MOLECULAR AND NEW MORPHOLOGICAL DATA ON NEMATODE HEDRURIS DRATINI FOUND PARASITIZING PSEUDIS MINUTA (ANURA: HYLIDAE)
Martin M. Montes, Yasmin Croci, Jorge Barneche, Dario Balcazar, German F. Reig Cardarella, Sergio R. Martorelli
CLITELLATE (ANNELIDA: CLITELLATA) PARASITES AND PREDATORS OF NORTH AMERICAN HERPETOFAUNA: CHECKLIST OF SPECIES, IDENTIFICATION KEY, AND A NEW RECORD FOR MEXICO
Manuel De Luna, Roberto García-Barrios, Diane P. Barton, Leonardo García-Vázquez
LOUSY ASSOCIATIONS: SUCKING LICE (PHTHIRAPTERA: ANOPLURA) PARASITIZING RODENTS AND LAGOMORPHS IN THE DESERT NATIONAL WILDLIFE REFUGE, NEVADA
Sara B. Weinstein, John P. Dumbacher, Lance A. Durden
A NEW SPECIES OF ACANTHOBOTHRIUM (CESTODA: ONCHOPROTEOCEPHALIDEA), PARASITE OF THE GIANT ELECTRIC RAY NARCINE ENTEMEDOR JORDAN AND STARKS, 1895 (BATOIDEA: TORPEDINIFORMES) FROM MEXICO
Erick Rodríguez-Ibarra, Berenice Adán-Torres, Fernando Ruiz-Escobar, Gerardo Torres-Carrera
SEROPREVALENCE OF TOXOPLASMA GONDII IN GOATS FROM SOUTHWESTERN MISSISSIPPI, USA
Alexander D. W. Acholonu, Jamela S. Alexander