Interleukin (IL-)7 and thyroxin (T4) favor Schistosoma mansoni development. Their effect is similar, rather than identical; moreover, cotreatment acts synergistically on parasites. This questioned a common mediator to their action, which we hypothesized was host glucose metabolism. Infection with S. mansoni resulted in an early peak in glycemia immediately followed by a peak of insulinemia (D7-21). In IL-7 + T4 cotreated infected animals, the peak of insulin was abrogated. We further assessed the consequences of experimentally induced glucose- or insulin-level variations on parasite development. Insulin treatment from day 14 to day 21 post-infection (PI) led to increased worm burden and parasite size, thus mimicking the effect of T4 on schistosome development. Interestingly, insulin treatment did not modify glycemia yet abrogated the hyperinsulinemia, normally occurring during infection. Finally, these treatments were associated with an alteration of the expression of parasite genes involved in glucose uptake. These experiments characterize the elaborate links between parasite and host metabolism and their reciprocal influences.
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August 2005
BIOCHEMISTRY-PHYSIOLOGY|
August 01 2005
HOST GLUCOSE METABOLISM MEDIATES T4 AND IL-7 ACTION ON SCHISTOSOMA MANSONI DEVELOPMENT Available to Purchase
Pasquine Saule;
Pasquine Saule
UMR 8527 CNRS Institut de Biologie de Lille, Lille, France 59 021. [email protected]
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Jérôme Vicogne;
Jérôme Vicogne
* U 567 INSERM Institut Pasteur de Lille, Lille, France 59 019
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Myriam Delacre;
Myriam Delacre
UMR 8527 CNRS Institut de Biologie de Lille, Lille, France 59 021. [email protected]
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Laurence Macia;
Laurence Macia
UMR 8527 CNRS Institut de Biologie de Lille, Lille, France 59 021. [email protected]
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Anne Tailleux;
Anne Tailleux
† U 545 INSERM Institut Pasteur de Lille, Lille, France 59 019
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Colette Dissous;
Colette Dissous
* U 567 INSERM Institut Pasteur de Lille, Lille, France 59 019
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Claude Auriault;
Claude Auriault
UMR 8527 CNRS Institut de Biologie de Lille, Lille, France 59 021. [email protected]
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Isabelle Wolowczuk
Isabelle Wolowczuk
UMR 8527 CNRS Institut de Biologie de Lille, Lille, France 59 021. [email protected]
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J Parasitol (2005) 91 (4): 737–744.
Citation
Pasquine Saule, Jérôme Vicogne, Myriam Delacre, Laurence Macia, Anne Tailleux, Colette Dissous, Claude Auriault, Isabelle Wolowczuk; HOST GLUCOSE METABOLISM MEDIATES T4 AND IL-7 ACTION ON SCHISTOSOMA MANSONI DEVELOPMENT. J Parasitol 1 August 2005; 91 (4): 737–744. doi: https://doi.org/10.1645/GE-3402.1
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