We demonstrate here that dipalmitoylphosphatidylcholine (DPPC) liposome has an antitrypanosomal effect, especially against the bloodstream forms (BSFs) of African trypanosomes (Trypanosoma congolense, T. brucei rhodesiense, and T. brucei brucei). The DPPC liposome significantly decreased the in vitro percentage of viable and motile BSF African trypanosomes but only marginally reduced the percentage of viable and motile procyclic form (PCF) of trypanosomes. The DPPC liposome absorption was much more pronounced to BSF than to PCF trypanosomes. Administration of the DPPC liposome showed a slight but significant reduction in the early development of parasitemia in T. congolense–infected mice. These results suggest that parasites were killed by specific binding of the DPPC liposome to the trypanosomes. This work demonstrates for the first time that a liposome has antitrypanosomal activity.
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April 2006
Research Article|
April 01 2006
EFFICACY OF DIPALMITOYLPHOSPHATIDYLCHOLINE LIPOSOME AGAINST AFRICAN TRYPANOSOMES
Noritaka Kuboki;
Noritaka Kuboki
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. yokoyama@obihiro.ac.jp
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Naoaki Yokoyama;
Naoaki Yokoyama
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. yokoyama@obihiro.ac.jp
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Naoya Kojima;
Naoya Kojima
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. yokoyama@obihiro.ac.jp
* The Institute of Glycotechnology and the Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259–1292, Japan
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Tatsuya Sakurai;
Tatsuya Sakurai
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. yokoyama@obihiro.ac.jp
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Noboru Inoue;
Noboru Inoue
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. yokoyama@obihiro.ac.jp
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Chihiro Sugimoto
Chihiro Sugimoto
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. yokoyama@obihiro.ac.jp
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J Parasitol (2006) 92 (2): 389–393.
Citation
Noritaka Kuboki, Naoaki Yokoyama, Naoya Kojima, Tatsuya Sakurai, Noboru Inoue, Chihiro Sugimoto; EFFICACY OF DIPALMITOYLPHOSPHATIDYLCHOLINE LIPOSOME AGAINST AFRICAN TRYPANOSOMES. J Parasitol 1 April 2006; 92 (2): 389–393. doi: https://doi.org/10.1645/GE-667R.1
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