The experiments were conducted to determine intrasporozoite Na+/K+ concentrations (by AAS) and membrane-bound Na+-K+-ATPase activity (measured by UV-VIS with a Na+-K+-ATPase Detection Kit) of Eimeria tenella sporozoites of the sensitive line (i.e., the parent line, coded as OS) and 2 resistant lines, derived from the parent line (coded as OR125 and OR200), with and without in vitro exposure to monensin. These parameters for OR125 and OR200 were significantly lower than those for OS. In vitro exposure to monensin increased intrasporozoite Na+/K+ concentrations and Na+-K+-ATPase activity, but the stimulation on OS was significantly higher than those on OR125 and OR200, indicating that monensin had less effect on resistant parasites. The results of this study suggest that altered biochemical or physiological properties, or both, in the membranes of E. tenella might be related to a reduced sensitivity to monensin.
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October 2006
Research Article|
October 01 2006
INFLUENCE OF MONENSIN ON CATION INFLUX AND NA+-K+-ATPase ACTIVITY OF EIMERIA TENELLA SPOROZOITES IN VITRO
Zhuo Wang;
Zhuo Wang
Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, P.R. China. sjz@cau.edu.cn
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Xun Suo;
Xun Suo
Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, P.R. China. sjz@cau.edu.cn
* Department of Parasitology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, P.R. China
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Xi Xia;
Xi Xia
Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, P.R. China. sjz@cau.edu.cn
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Jianzhong Shen
Jianzhong Shen
Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, P.R. China. sjz@cau.edu.cn
† To whom correspondence should be addressed
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J Parasitol (2006) 92 (5): 1092–1096.
Citation
Zhuo Wang, Xun Suo, Xi Xia, Jianzhong Shen; INFLUENCE OF MONENSIN ON CATION INFLUX AND NA+-K+-ATPase ACTIVITY OF EIMERIA TENELLA SPOROZOITES IN VITRO. J Parasitol 1 October 2006; 92 (5): 1092–1096. doi: https://doi.org/10.1645/GE-783R.1
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