Alkyl-lysophospholipids (ALPs), developed initially to be antitumor agents, have proved highly effective in the treatment of visceral leishmaniasis, a disease caused by the species making up the protozoan complex Leishmania donovani. Although their effectiveness is known, the mode of action against this parasite is not completely understood. In the present work, we have studied the effect of 3 derivatives, edelfosine, miltefosine, and ilmofosine. Using nuclear magnetic resonance spectroscopy (1H-NMR), we have examined the excreted catabolites from glucose metabolism in the promastigote forms treated with these compounds. The ALPs at concentrations of 19 and 38 μM inhibit the excretion of acetate, succinate, and pyruvate. The effect of edelfosine, miltefosine, and ilmofosine on the activity of the enzymes hexokinase, glycerolkinase 3-PD, phosphoglucose isomerase, superoxide dismutase, and phospholipase C were also examined. Glycerolkinase 3-PD and phosphoglucose isomerase are generally insensitive to the compounds, whereas hexokinase and superoxide dismutase are inhibited by miltefosine and ilmofosine. The ALPs exhibited an activated effect against the phospholipase C activity. Alkyl-lysophospholipids were shown to have a significant effect on several enzymes in important biochemical pathways indispensable for the survival of L. donovani promasigotes.
Skip Nav Destination
Article navigation
October 2007
THERAPEUTICS-DIAGNOSTICS|
October 01 2007
EFFECT OF ALKYL-LYSOPHOSPHOLIPIDS ON SOME ASPECTS OF THE METABOLISM OF LEISHMANIA DONOVANI
S. Azzouz;
S. Azzouz
Institute of Biotechnology, Department of Parasitology, Faculty of Sciences Campus Fuentenueva C.P.: 18071, Granada, Spain. [email protected]
Search for other works by this author on:
M. Maache;
M. Maache
Institute of Biotechnology, Department of Parasitology, Faculty of Sciences Campus Fuentenueva C.P.: 18071, Granada, Spain. [email protected]
Search for other works by this author on:
M. Sánchez-Moreno;
M. Sánchez-Moreno
Institute of Biotechnology, Department of Parasitology, Faculty of Sciences Campus Fuentenueva C.P.: 18071, Granada, Spain. [email protected]
Search for other works by this author on:
A. F. Petavy;
A. F. Petavy
Institute of Biotechnology, Department of Parasitology, Faculty of Sciences Campus Fuentenueva C.P.: 18071, Granada, Spain. [email protected]
* Department of Parasitology (Pr. Petavy) Faculty of Pharmacy, University Claude Bernard-Lyon I, 8, avenue Rockefeller, 69373 Lyon Cedex 08, France
Search for other works by this author on:
A. Osuna
A. Osuna
Institute of Biotechnology, Department of Parasitology, Faculty of Sciences Campus Fuentenueva C.P.: 18071, Granada, Spain. [email protected]
Search for other works by this author on:
J Parasitol (2007) 93 (5): 1202–1207.
Citation
S. Azzouz, M. Maache, M. Sánchez-Moreno, A. F. Petavy, A. Osuna; EFFECT OF ALKYL-LYSOPHOSPHOLIPIDS ON SOME ASPECTS OF THE METABOLISM OF LEISHMANIA DONOVANI. J Parasitol 1 October 2007; 93 (5): 1202–1207. doi: https://doi.org/10.1645/GE-1086R1.1
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
LOUSY ASSOCIATIONS: SUCKING LICE (PHTHIRAPTERA: ANOPLURA) PARASITIZING RODENTS AND LAGOMORPHS IN THE DESERT NATIONAL WILDLIFE REFUGE, NEVADA
Sara B. Weinstein, John P. Dumbacher, Lance A. Durden
A NEW SPECIES OF ACANTHOBOTHRIUM (CESTODA: ONCHOPROTEOCEPHALIDEA), PARASITE OF THE GIANT ELECTRIC RAY NARCINE ENTEMEDOR JORDAN AND STARKS, 1895 (BATOIDEA: TORPEDINIFORMES) FROM MEXICO
Erick Rodríguez-Ibarra, Berenice Adán-Torres, Fernando Ruiz-Escobar, Gerardo Torres-Carrera
SEROPREVALENCE OF TOXOPLASMA GONDII IN GOATS FROM SOUTHWESTERN MISSISSIPPI, USA
Alexander D. W. Acholonu, Jamela S. Alexander
TAXES OF DICYEMIDS (PHYLUM DICYEMIDA)
Naoki Hisayama, Yuto Takeuchi, Hidetaka Furuya
TRICHINELLA MURRELLI POZIO AND LA ROSA, 2000 IN A GRAY FOX (UROCYON CINEREOARGENTEUS) FROM PENNSYLVANIA: A NEW HOST RECORD FOR THIS ZOONOTIC NEMATODE
P. C. Thompson, L. S. de Araujo, A. Gupta, S. Kay, O. C. H. Kwok, J. Battle, K. Van Why, J. D. Brown, B. M. Rosenthal, J. P. Dubey