Because the synthetic trioxolane OZ78 is active against the liver fluke Fasciola hepatica, we were motivated to investigate the in vivo and in vitro activity against another liver fluke, namely Clonorchis sinensis. Rats infected with C. sinensis for 2 and 5 wk were treated orally with single doses of OZ78 (75, 150, or 300 mg/kg). Worm burden reductions were assessed against untreated control rats. Scanning electron microscopy (SEM) was used to observe adult C. sinensis after recovery from rats 1–3 days posttreatment with a single 300 mg/kg oral dose of OZ78 and after in vitro exposure to concentrations of 1, 10, and 100 μg/ml of OZ78. A single 300 mg/kg oral dose of OZ78 resulted in worm burden reductions of 78.5% and 98.5% against juvenile and adult C. sinensis, respectively. SEM observations revealed tegumental surface alterations, including blebbing and sloughing. OZ78 emerges as a new compound with a broad spectrum of activity against major foodborne trematode infections.
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October 2007
THERAPEUTICS-DIAGNOSTICS|
October 01 2007
CLONORCHICIDAL PROPERTIES OF THE SYNTHETIC TRIOXOLANE OZ78 Available to Purchase
Jennifer Keiser;
Jennifer Keiser
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. [email protected]
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Shu-Hua Xiao;
Shu-Hua Xiao
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. [email protected]
* National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, People's Republic of China
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Yuxiang Dong;
Yuxiang Dong
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. [email protected]
† College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025
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Jürg Utzinger;
Jürg Utzinger
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. [email protected]
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Jonathan L. Vennerstrom
Jonathan L. Vennerstrom
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. [email protected]
† College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025
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J Parasitol (2007) 93 (5): 1208–1213.
Citation
Jennifer Keiser, Shu-Hua Xiao, Yuxiang Dong, Jürg Utzinger, Jonathan L. Vennerstrom; CLONORCHICIDAL PROPERTIES OF THE SYNTHETIC TRIOXOLANE OZ78. J Parasitol 1 October 2007; 93 (5): 1208–1213. doi: https://doi.org/10.1645/GE-1143R.1
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