Eight female Peromyscus californicus were infected with 102 or 104 Toxoplasma gondii culture-derived tachyzoites (Type II or X) isolated from southern sea otters. All but 2 mice survived infection and developed antibodies to T. gondii. The 2 fatally infected mice were inoculated with 104 tachyzoites of the Type X strain. Parasite detection by immunohistochemistry (IHC) and DNA amplification with 2 polymerase chain reaction (PCR) methods was compared for brain, heart, lung, liver, spleen, biceps muscle, and tongue, at a mean of 41 days postinfection. Parasites were detected most commonly by IHC in spleen (8/8) and brain (6/8). DNA amplification by PCR was most successful from brain, heart, and spleen.
EXPERIMENTAL INFECTION OF PEROMYSCUS CALIFORNICUS WITH TOXOPLASMA GONDII
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Haydee A. Dabritz, Melissa A. Miller, Andrea E. Packham, Daniel Rejmanek, Christian M. Leutenegger, Ian A. Gardner, E. Robert Atwill, Patricia A. Conrad; EXPERIMENTAL INFECTION OF PEROMYSCUS CALIFORNICUS WITH TOXOPLASMA GONDII. J Parasitol 1 December 2007; 93 (6): 1360–1364. doi: https://doi.org/10.1645/GE-1210.1
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