To evaluate higher-level affinities of Hepatozoon species within Apicomplexa, we sequenced the 18S rRNA gene from 2 parasites (Hepatozoon americanum and Hepatozoon canis) of dogs and 1 (Hepatozoon catesbianae) of bullfrogs. Sequences from other apicomplexans among the Sarcocystiidae, Eimeriidae, Theileriidae, Plasmodiidae, Cryptosporiidae, and Babesiidae, a Perkinsus species and 2 dinoflagellates were obtained from GenBank. Phylogenetic analysis indicated that Plasmodium, Cryptosporidium, and Hepatozoon form a monophyletic group distinct from representatives of other apicomplexan families. Although equivocal, our analysis indicated that Plasmodium and Cryptosporidium are sister taxa and that Hepatozoon is basal to them. To evaluate phylogenetic affinities among H. americanum, H. canis, and other species of Hepatozoon, we examined 18 morphologic and life-cycle features of 13 species currently assigned to Hepatozoon. This analysis indicates paraphyly of Hepatozoon (as currently arranged) because Hepatozoon lygosomarum was found most closely related to Hemolivia mauritanicum. These results, combined with results of previous studies, support elevating Hepatozoon to familial level (Hepatozoidae) as originally suggested by Wenyon in 1926. Both DNA sequence data and morphologic and life-cycle characters support a sister-group relationship between H. americanum and H. canis.
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April 2000
SYSTEMATICS-PHYLOGENETICS|
April 01 2000
PHYLOGENETIC RELATIONSHIPS OF HEPATOZOON (APICOMPLEXA: ADELEORINA) BASED ON MOLECULAR, MORPHOLOGIC, AND LIFE-CYCLE CHARACTERS
J. S. Mathew;
J. S. Mathew
Department of Infectious Diseases and Physiology, Oklahoma State University, Stillwater, Oklahoma 74078
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R. A. Van Den Bussche;
R. A. Van Den Bussche
Department of Infectious Diseases and Physiology, Oklahoma State University, Stillwater, Oklahoma 74078
*Department of Zoology, Oklahoma State University, Stillwater, Oklahoma 74078.
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S. A. Ewing;
S. A. Ewing
Department of Infectious Diseases and Physiology, Oklahoma State University, Stillwater, Oklahoma 74078
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J. R. Malayer;
J. R. Malayer
Department of Infectious Diseases and Physiology, Oklahoma State University, Stillwater, Oklahoma 74078
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B. R. Latha;
B. R. Latha
Department of Infectious Diseases and Physiology, Oklahoma State University, Stillwater, Oklahoma 74078
†Department of Veterinary Parasitology, Madras Veterinary College, Madras, India 600 007.
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R. J. Panciera
R. J. Panciera
Department of Infectious Diseases and Physiology, Oklahoma State University, Stillwater, Oklahoma 74078
‡Department of Anatomy, Pathology and Pharmacology, Oklahoma State University, Stillwater, Oklahoma 74078.
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J Parasitol (2000) 86 (2): 366–372.
Citation
J. S. Mathew, R. A. Van Den Bussche, S. A. Ewing, J. R. Malayer, B. R. Latha, R. J. Panciera; PHYLOGENETIC RELATIONSHIPS OF HEPATOZOON (APICOMPLEXA: ADELEORINA) BASED ON MOLECULAR, MORPHOLOGIC, AND LIFE-CYCLE CHARACTERS. J Parasitol 1 April 2000; 86 (2): 366–372. doi: https://doi.org/10.1645/0022-3395(2000)086[0366:PROHAA]2.0.CO;2
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