The Three W's of Acetaminophen In Children: Who, Why, and Which Administration Mode?

Thibault, Céline; Pelletier, Élaine; Nguyen, Christina; Trottier, Evelyne D.; Doré-Bergeron, Marie-Joëlle; DeKoven, Kathryn; Roy, Anne-Marie; Piché, Nelson; Delisle, Jean-Francois; Morin, Caroline; Paquette, Julie; Kleiber, Niina

doi:10.5863/1551-6776-28.1.20

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EDUCATION| February 03 2023

The Three W's of Acetaminophen In Children: Who, Why, and Which Administration Mode?

Céline Thibault, MD, PhD;

Céline Thibault, MD, PhD

Department of Pharmacology and Physiology (CT, NK), Université de Montreal, Montreal, QC, Canada

Research Center (CT, NK), CHU Sainte-Justine, Université de Montreal, Montreal, QC, Canada

Department of Pediatrics (CT, MJDB, NK), CHU Sainte-Justine, Montreal, QC, Canada

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Correspondence. Céline Thibault, MD, PhD; celine.thibault@umontreal.ca

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Élaine Pelletier, BPharm, MSc;

Élaine Pelletier, BPharm, MSc

Department of Pharmacology and Physiology (CT, NK), Université de Montreal, Montreal, QC, Canada

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Pharmacy (EP, CN, JFD, CM), CHU Sainte-Justine, Montreal, QC, Canada

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Christina Nguyen, BPharm, MSc;

Christina Nguyen, BPharm, MSc

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Pharmacy (EP, CN, JFD, CM), CHU Sainte-Justine, Montreal, QC, Canada

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Evelyne D. Trottier, MD;

Evelyne D. Trottier, MD

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Pediatric Emergency Medicine (EDT), CHU Sainte Justine, Montreal, QC, Canada

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Marie-Joëlle Doré-Bergeron, MD;

Marie-Joëlle Doré-Bergeron, MD

Department of Pediatrics (CT, MJDB, NK), CHU Sainte-Justine, Montreal, QC, Canada

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

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Kathryn DeKoven, MD;

Kathryn DeKoven, MD

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Anesthesiology (KD), CHU Sainte-Justine, Montreal, QC, Canada

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Anne-Marie Roy, BSc;

Anne-Marie Roy, BSc

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Nursing (AMR, JP), CHU Sainte-Justine, Montreal, QC, Canada

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Nelson Piché, MD, MSc;

Nelson Piché, MD, MSc

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

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Jean-Francois Delisle, BSc, BPharm, DESS, MSc;

Jean-Francois Delisle, BSc, BPharm, DESS, MSc

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Pharmacy (EP, CN, JFD, CM), CHU Sainte-Justine, Montreal, QC, Canada

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Caroline Morin, BPharm, MSc;

Caroline Morin, BPharm, MSc

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Pharmacy (EP, CN, JFD, CM), CHU Sainte-Justine, Montreal, QC, Canada

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Julie Paquette, MSc;

Julie Paquette, MSc

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Nursing (AMR, JP), CHU Sainte-Justine, Montreal, QC, Canada

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Niina Kleiber, MD, PhD

Department of Pharmacology and Physiology (CT, NK), Université de Montreal, Montreal, QC, Canada

Research Center (CT, NK), CHU Sainte-Justine, Université de Montreal, Montreal, QC, Canada

Groupe de Gouvernance des Analgésiques (CT, EP, CN, EDT, MJDB, KD, AMR, NP, JFD, CM, JP, NK), Pharmacology Committee, CHU Sainte-Justine, Montreal, QC, Canada

Department of Surgery (NP), CHU Sainte-Justine, Montreal, QC, Canada

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The Journal of Pediatric Pharmacology and Therapeutics (2023) 28 (1): 20–28.

https://doi.org/10.5863/1551-6776-28.1.20

Acetaminophen is one of the oldest medications commonly administered in children. Its efficacy in treating fever and pain is well accepted among clinicians. However, the available evidence supporting the use of acetaminophen's different modes of administration remains relatively scarce and poorly known. This short report summarizes the available evidence and provides a framework to guide clinicians regarding a rational use of acetaminophen in children.

2023

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