Klebsiella pneumoniae is a zoonotic, Gram-negative member of the family Enterobacteriaceae and is the causative agent of nosocomial septicemic, pneumonic, and urinary tract infections. Recently, pathogenic strains of K. pneumoniae sharing a hypermucoviscosity (HMV) phenotype have been attributed to multisystemic abscessation in both human and nonhuman primates. Although K. pneumoniae is a well-recognized zoonotic agent, there is a lack of general information including adequate diagnostic methods or treatments for nonhuman primates. In an effort to increase the body of knowledge of this enigmatic pathogen, K. pneumoniae isolates from African green monkeys (Chlorocebus aethiops sabaeus) on the island of St. Kitts, West Indies were genotypically and phenotypically characterized. Genetic fingerprints generated by PCR-mediated genomic fingerprinting, phenotypic characterization, and antimicrobial susceptibility all identified a high degree of similarity between the HMV and non-HMV K. pneumoniae isolates. The results obtained from this work will help establish a baseline for the development of efficacious diagnostic methods and treatment strategies for both human and nonhuman primates.
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DIAGNOSTICS|
July 01 2012
PHENOTYPIC AND GENOTYPIC CHARACTERIZATION OF KLEBSIELLA PNEUMONIAE ISOLATES RECOVERED FROM NONHUMAN PRIMATES
Esteban Soto;
Esteban Soto
4
1 Ross University School of Veterinary Medicine, Main Island Rd., West Farm, St. Kitts, West Indies
4 Corresponding author (email: [email protected])
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Virginia LaMon;
Virginia LaMon
1 Ross University School of Veterinary Medicine, Main Island Rd., West Farm, St. Kitts, West Indies
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Matt Griffin;
Matt Griffin
2 Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, PO Box 197, Stoneville, Mississippi 38776, USA
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Natalie Keirstead;
Natalie Keirstead
1 Ross University School of Veterinary Medicine, Main Island Rd., West Farm, St. Kitts, West Indies
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Amy Beierschmitt;
Amy Beierschmitt
3 Behavioural Science Foundation, PO Box 428, Estridge Estate, St. Kitts, West Indies
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Roberta Palmour
Roberta Palmour
3 Behavioural Science Foundation, PO Box 428, Estridge Estate, St. Kitts, West Indies
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J Wildl Dis (2012) 48 (3): 603–611.
Article history
Received:
November 17 2011
Accepted:
March 05 2012
Citation
Esteban Soto, Virginia LaMon, Matt Griffin, Natalie Keirstead, Amy Beierschmitt, Roberta Palmour; PHENOTYPIC AND GENOTYPIC CHARACTERIZATION OF KLEBSIELLA PNEUMONIAE ISOLATES RECOVERED FROM NONHUMAN PRIMATES. J Wildl Dis 1 July 2012; 48 (3): 603–611. doi: https://doi.org/10.7589/0090-3558-48.3.603
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